{"id":"W4200439951","doi":"10.1016/j.neo.2021.11.012","title":"Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells","year":2021,"lang":"en","type":"article","venue":"Neoplasia","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Wellcome Trust; Shenzhen Gas Corporation; Innovative Medicines Initiative; Takeda Pharmaceutical Company; Dr. Mildred Scheel Stiftung für Krebsforschung; Genentech; Deutsche Krebshilfe; Canada Foundation for Innovation; Ontario Genomics Institute; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Merck Canada; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceuticals U.S.A.; McGill University; Boehringer Ingelheim; Janssen Pharmaceuticals; Pfizer UK; Merck KGaA; Merck; Bayer; Pfizer","keywords":"Apoptosis; Bromodomain; Chemistry; Downregulation and upregulation; Bcl-xL; Cancer research; Cell biology; Gene silencing; Caspase; Programmed cell death; Biology; Epigenetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269063,0.0002989512,0.0003081591,0.0002345581,0.0001002014,0.0001586752,0.0001270778,0.0001951753,0.001055119],"category_scores_gemma":[0.00005830822,0.0001095957,0.0002660263,0.0001787586,0.0001032326,0.0001657601,0.0001575379,0.0003952679,0.0003203377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174819,"about_ca_system_score_gemma":0.0001503244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002715903,"about_ca_topic_score_gemma":0.0007143629,"domain_scores_codex":[0.9998858,0.00002029867,0.0000115541,0.00001261743,0.00003874702,0.00003093286],"domain_scores_gemma":[0.9999635,0.00000800725,0.000009165976,0.0000044228,0.000004846117,0.00001000031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600219,0.00008155511,0.0001612257,0.00005402996,0.000008488565,0.0000578084,0.00001460246,0.0001157402,0.997471,0.00007301891,0.00005467628,0.001647823],"study_design_scores_gemma":[0.00006640931,0.0009394689,0.003929868,0.000003866252,0.0000196231,0.0002898861,0.00002412033,0.0006843476,0.9918296,0.00004775716,0.002160969,0.000003946735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954921,0.001316352,0.001103139,0.00006301102,0.00002149987,0.00005334209,0.0002568601,0.00006011373,0.001633611],"genre_scores_gemma":[0.9963762,0.0007879462,0.0008180508,0.00003996128,0.000007636933,0.00004282483,0.0004236792,0.000007670576,0.001496076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055119,"threshold_uncertainty_score":0.003529727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005437093063722288,"score_gpt":0.2163432908602652,"score_spread":0.210906197796543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}