{"id":"W4200439951","doi":"10.1016/j.neo.2021.11.012","title":"Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells","year":2021,"lang":"en","type":"article","venue":"Neoplasia","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Wellcome Trust; Shenzhen Gas Corporation; Innovative Medicines Initiative; Takeda Pharmaceutical Company; Dr. Mildred Scheel Stiftung für Krebsforschung; Genentech; Deutsche Krebshilfe; Canada Foundation for Innovation; Ontario Genomics Institute; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Merck Canada; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceuticals U.S.A.; McGill University; Boehringer Ingelheim; Janssen Pharmaceuticals; Pfizer UK; Merck KGaA; Merck; Bayer; Pfizer","keywords":"Apoptosis; Bromodomain; Chemistry; Downregulation and upregulation; Bcl-xL; Cancer research; Cell biology; Gene silencing; Caspase; Programmed cell death; Biology; Epigenetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006420755,0.0001784981,0.0001690191,0.00008766601,0.0000577851,0.00004194779,0.00008786257,0.0001959893,0.00003251498],"category_scores_gemma":[0.0001004172,0.0001760371,0.00005455882,0.0004321789,0.00003599988,0.000008455264,0.00008234828,0.0001592962,0.00003337742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004378029,"about_ca_system_score_gemma":0.0002022623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002911932,"about_ca_topic_score_gemma":0.0002785545,"domain_scores_codex":[0.9987749,0.0001004426,0.0002163107,0.0004543654,0.0001874834,0.0002664703],"domain_scores_gemma":[0.9993639,0.00001589735,0.0000613237,0.0002835938,0.0001556759,0.0001195824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001770431,0.0001089043,0.0006690005,0.00001039323,0.00002247012,0.00001070346,0.00009804848,0.00006415637,0.9912239,0.00006711024,0.006707211,0.0008410291],"study_design_scores_gemma":[0.001028635,0.0003560392,0.0007279062,0.00004302755,0.00001079514,0.00001792276,0.0001057908,0.000008900017,0.9799009,0.00003485372,0.0175394,0.0002258483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956295,0.00006804147,0.001513746,0.0004921443,0.0002888464,0.0003066531,0.00002221309,0.00001647543,0.001662418],"genre_scores_gemma":[0.9911233,0.00002254271,0.006942491,0.0006732478,0.0003094808,0.00007152309,0.0001669741,0.00002816428,0.0006622776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01132305,"threshold_uncertainty_score":0.7178584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005437093063722288,"score_gpt":0.2163432908602652,"score_spread":0.210906197796543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}