{"id":"W4200442084","doi":"10.1158/1535-7163.targ-21-lba030","title":"Abstract LBA030: DPX-SurMAGE, a novel dual-targeted immunotherapy for bladder cancer, induces target-specific T cells with a favorable safety profile in preclinical model","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dartmouth General Hospital; Université Laval","funders":"","keywords":"Survivin; Immunotherapy; Immunogenicity; Bladder cancer; Cystectomy; T cell; Cancer immunotherapy; Medicine; Cancer research; Antigen; Immune system; Immunology; Major histocompatibility complex; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678988,0.0003605954,0.0002069611,0.0001645124,0.00009861186,0.0001899658,0.000205142,0.0003886779,0.001809709],"category_scores_gemma":[0.0000632894,0.0001105169,0.0002064172,0.0001276901,0.0001225346,0.0001933451,0.00012317,0.0008296825,0.0005163407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091244,"about_ca_system_score_gemma":0.0002162148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005105197,"about_ca_topic_score_gemma":0.0004556524,"domain_scores_codex":[0.9998946,0.00001468904,0.000005736226,0.0000252413,0.00002843504,0.00003117877],"domain_scores_gemma":[0.9999608,0.000003956532,0.0000105291,0.000004282203,0.000006583176,0.00001390028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004187452,0.0002477715,0.0001179851,0.00009075088,0.000007697422,0.00003030838,0.00001362741,0.000207425,0.9930935,0.0001040104,0.0004152042,0.00525303],"study_design_scores_gemma":[0.0001049049,0.004073182,0.001313083,0.00001044396,0.00002279611,0.0002318998,0.00001325939,0.00170178,0.9872724,0.00004677847,0.005204043,0.000005381933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799279,0.003598047,0.01017664,0.0002201081,0.0001491828,0.0001521768,0.0008646092,0.000402461,0.004508847],"genre_scores_gemma":[0.9890082,0.0009705927,0.002926808,0.0001075427,0.00001556672,0.0001226341,0.0008489655,0.00002382318,0.005975803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809709,"threshold_uncertainty_score":0.006054103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04251056014399972,"score_gpt":0.3076973681305927,"score_spread":0.265186807986593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}