{"id":"W4200445102","doi":"10.1093/nar/gkab1188","title":"The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Jewish General Hospital","funders":"Vicerrectoría de Investigación, Creación e Innovación; Canadian Institutes of Health Research; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; Jewish General Hospital","keywords":"Internal ribosome entry site; Biology; Translation (biology); Untranslated region; RNA; HEK 293 cells; Virology; RNA-binding protein; Cell biology; RNA silencing; Messenger RNA; Molecular biology; RNA interference; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342733,0.0006315482,0.0003540011,0.0004022252,0.0005303318,0.0005300589,0.0002807182,0.000484365,0.0009725333],"category_scores_gemma":[0.0002241779,0.0001970728,0.0003324997,0.0002677191,0.0003290404,0.0003031893,0.0003190852,0.0003838035,0.0006382893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007841842,"about_ca_system_score_gemma":0.0002494948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008261903,"about_ca_topic_score_gemma":0.0008929478,"domain_scores_codex":[0.9998578,0.00001780703,0.00001026955,0.00004490083,0.00004269392,0.00002659812],"domain_scores_gemma":[0.999869,0.00002049922,0.00005631669,0.00001086256,0.00001376263,0.00002970725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006943161,0.00001622536,0.0005747169,0.00008717732,0.000008160468,0.00011678,0.00002116184,0.0001670498,0.9937391,0.0003449361,0.0001453007,0.004709906],"study_design_scores_gemma":[0.000006533884,0.00007432637,0.005960104,0.000009967973,0.00001007262,0.0006369557,0.00002073361,0.001372962,0.9825174,0.0001148559,0.009267514,0.000008539901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651229,0.01732669,0.01350705,0.0002887764,0.00007066863,0.00005927875,0.001097359,0.0004236937,0.002103585],"genre_scores_gemma":[0.9851727,0.003588951,0.00537934,0.00005361411,0.000022737,0.00003807082,0.001587426,0.00003477383,0.004122331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009725333,"threshold_uncertainty_score":0.00568974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0811756030998868,"score_gpt":0.3536679805890274,"score_spread":0.2724923774891406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}