{"id":"W4200448664","doi":"10.1002/alz.12485","title":"Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Western University; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"Janssen Pharmaceuticals; NIHR Cambridge Biomedical Research Centre; UK Dementia Research Institute; Instituto de Salud Carlos III; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Medical Research Council; Department of Health and Social Care; Neuraxpharm; Evelyn Trust; University of Cambridge; Bundesministerium für Bildung und Forschung; Guarantors of Brain; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Astex Pharmaceuticals; Agence Nationale de la Recherche; Alzheimer's Society; Deutsche Forschungsgemeinschaft; Brain Research UK; Ionis Pharmaceuticals; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Biogen","keywords":"Frontotemporal dementia; Disease; Dementia; Psychology; Operationalization; Medicine; Neuroscience; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01911523,0.001645077,0.001350361,0.008911852,0.002956562,0.00713097,0.005614853,0.004569234,0.003150364],"category_scores_gemma":[0.01437815,0.0005403169,0.002171597,0.005593982,0.01686027,0.009355647,0.004391673,0.007308508,0.001594593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008915217,"about_ca_system_score_gemma":0.01359602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01029646,"about_ca_topic_score_gemma":0.008525112,"domain_scores_codex":[0.9926077,0.00443168,0.001021337,0.0006551038,0.0008404687,0.0004436953],"domain_scores_gemma":[0.9915173,0.004100505,0.001213565,0.0002505076,0.002060769,0.0008573295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005311462,0.00006519082,0.001457719,0.0007424346,0.00002758358,0.0004425444,0.009655602,0.0003891465,0.0003288485,0.9474868,0.01220954,0.02714149],"study_design_scores_gemma":[0.00007114548,0.000209263,0.003797217,0.004076386,0.00010359,0.003029072,0.0114036,0.001983214,0.000195537,0.6499084,0.3251229,0.00009964256],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02259612,0.2712622,0.3295427,0.2104536,0.01095956,0.002101073,0.00205563,0.0003653554,0.1506638],"genre_scores_gemma":[0.4213631,0.1006586,0.4098355,0.03883461,0.00710329,0.006786373,0.003120919,0.0002354951,0.01206204],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01911523,"threshold_uncertainty_score":0.1010922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1290108896806685,"score_gpt":0.3641156903888825,"score_spread":0.235104800708214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}