{"id":"W4200449008","doi":"10.1101/2021.12.03.471189","title":"Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Life Science Foundation of Japan; Ministry of Education, Culture, Sports, Science and Technology; Tokyo Biochemical Research Foundation; University of Tokyo; Naito Foundation","keywords":"Ribosome biogenesis; Ribosomal RNA; Ribosome; Ribosomal protein; Protein biosynthesis; Glutamine; Biology; Translation (biology); Cell biology; Elongation factor; Biogenesis; Eukaryotic Ribosome; RNA; Biochemistry; Messenger RNA; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006972507,0.0002633493,0.000238021,0.0003253791,0.0001107688,0.0002363,0.0001485576,0.0002139408,0.001585508],"category_scores_gemma":[0.00008639899,0.0001351118,0.0001556472,0.000159947,0.0001533536,0.00008833122,0.0001850928,0.0003631467,0.0003864202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601264,"about_ca_system_score_gemma":0.0001843302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000698717,"about_ca_topic_score_gemma":0.0007445226,"domain_scores_codex":[0.9999274,0.00001061145,0.000007147872,0.00001357463,0.0000244072,0.00001684204],"domain_scores_gemma":[0.9998924,0.00002382943,0.00002724777,0.00001407666,0.000007809557,0.00003461762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685118,0.00001766143,0.0004223412,0.00001364841,0.000005307815,0.0001297014,0.000005335693,0.00009316977,0.998077,0.00008677894,0.00008399577,0.0008965075],"study_design_scores_gemma":[0.00003329348,0.0004728352,0.008193834,0.000006093697,0.00001567044,0.001079005,0.00002202694,0.001001301,0.9854221,0.0001630269,0.003586573,0.000004298997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965253,0.0008768322,0.0006584359,0.00008372014,0.00002228325,0.00001383182,0.0005283813,0.0001180276,0.001173093],"genre_scores_gemma":[0.9967619,0.0003201883,0.0005835947,0.00001916826,0.000004594944,0.00001420582,0.0007200515,0.00001955004,0.001556704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585508,"threshold_uncertainty_score":0.005304098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009878843300247582,"score_gpt":0.2265918157397082,"score_spread":0.2167129724394606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}