{"id":"W4200460557","doi":"10.1089/hum.2021.131","title":"Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Medicine; Osteoarthritis; Genetic enhancement; Adverse effect; Surgery; Urology; Internal medicine; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005387782,0.0007113131,0.0005349959,0.0005501002,0.0002199351,0.0004295435,0.0002920642,0.000582715,0.001045857],"category_scores_gemma":[0.000271581,0.0001991009,0.0004827144,0.0001805861,0.0006714294,0.0006734437,0.0001356494,0.001068705,0.000300478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512514,"about_ca_system_score_gemma":0.0007652616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124338,"about_ca_topic_score_gemma":0.001277372,"domain_scores_codex":[0.9997491,0.00004501677,0.000024793,0.00005218542,0.00007552101,0.00005330921],"domain_scores_gemma":[0.9996923,0.00003596688,0.0001234746,0.00003759679,0.00004808226,0.00006265622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001369121,0.0008153706,0.0002008184,0.0001377701,0.00001208178,0.00003629025,0.00004738209,0.0002151102,0.9879469,0.0001343149,0.00008295649,0.009001816],"study_design_scores_gemma":[0.0001983159,0.02464787,0.002075667,0.00002106972,0.00008806371,0.000187818,0.00005513546,0.00109928,0.9696604,0.00005149684,0.001892076,0.00002272729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988314,0.003775415,0.005422645,0.0002226272,0.0001081556,0.0001875306,0.0003586781,0.0001719104,0.001438966],"genre_scores_gemma":[0.987258,0.003417429,0.004772617,0.00008370745,0.00005178505,0.0001857827,0.0005090968,0.00003556142,0.003686071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124338,"threshold_uncertainty_score":0.003498733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03805809938649879,"score_gpt":0.2899704237303296,"score_spread":0.2519123243438308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}