{"id":"W4200460557","doi":"10.1089/hum.2021.131","title":"Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Medicine; Osteoarthritis; Genetic enhancement; Adverse effect; Surgery; Urology; Internal medicine; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001408624,0.0003307778,0.0006875775,0.0001268292,0.000120989,0.00002523448,0.00006436442,0.0001414003,0.00009376613],"category_scores_gemma":[0.00001018229,0.0002839374,0.0001994818,0.0001564179,0.00008460477,0.00007745729,0.00001904686,0.00007953969,0.000002927528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008385742,"about_ca_system_score_gemma":0.0001670059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001594322,"about_ca_topic_score_gemma":0.0001013896,"domain_scores_codex":[0.9984232,0.00005262351,0.0004505671,0.0004985306,0.0001854309,0.0003896703],"domain_scores_gemma":[0.9990999,0.00005901166,0.0001051511,0.0004661329,0.0001239057,0.0001459424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002682343,0.001380319,0.0002335398,0.00001546349,0.0001260433,0.00007859378,0.001460477,0.0000295057,0.8834603,0.0005578132,0.00001413618,0.1099614],"study_design_scores_gemma":[0.08226822,0.009289152,0.0006130931,0.0001062206,0.00007608093,0.0001308323,0.0001054133,0.0001765327,0.9041428,0.0007695549,0.002063066,0.0002590631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832361,0.0132496,0.0007765461,0.0002902117,0.00008089512,0.002086687,0.0001131477,0.00004587883,0.0001209095],"genre_scores_gemma":[0.9813058,0.009053038,0.007447468,0.0003881399,0.0001464259,0.000388928,0.0003423528,0.00007914155,0.000848652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097023,"threshold_uncertainty_score":0.9999613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03805809938649879,"score_gpt":0.2899704237303296,"score_spread":0.2519123243438308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}