{"id":"W4200463735","doi":"10.1053/j.gastro.2021.11.037","title":"The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Cancer Council Tasmania; Cancer Council South Australia; Medical Research Council; Department of Health and Aged Care, Australian Government; Core Research for Evolutional Science and Technology; Ministry of Education, Culture, Sports, Science and Technology; Wellcome Trust; Lions Medical Research Foundation; Australian Government; Government of South Australia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Japan Agency for Medical Research and Development; Takeda Science Foundation","keywords":"Stromal cell; Cancer research; Biology; Carcinogenesis; Colorectal cancer; Cancer-Associated Fibroblasts; Cancer; Tumor microenvironment; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004297819,0.0001824151,0.0001698073,0.0008674614,0.000376369,0.0006849317,0.0001929218,0.0004233897,0.001155174],"category_scores_gemma":[0.000673966,0.0001253186,0.0001416124,0.0002798543,0.0003080671,0.0004701927,0.0003557693,0.0004226257,0.0003051237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002008099,"about_ca_system_score_gemma":0.0003062571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000835319,"about_ca_topic_score_gemma":0.001057374,"domain_scores_codex":[0.9997739,0.00008118581,0.00001414183,0.00002547528,0.00005754482,0.00004772731],"domain_scores_gemma":[0.9996835,0.0001089027,0.00003765337,0.00003600655,0.00006345448,0.00007058527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002406498,0.0001954862,0.07372125,0.0005176184,0.00006516503,0.005976054,0.001219414,0.0003479149,0.8205041,0.01356213,0.0007561446,0.08072834],"study_design_scores_gemma":[0.0001978216,0.002074159,0.3189417,0.0003243691,0.000252744,0.02693287,0.005760281,0.00361507,0.5569337,0.009971743,0.0749177,0.00007781992],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620675,0.02715285,0.002527385,0.0006911107,0.00008643206,0.00003578803,0.0001816373,0.00001911711,0.007238163],"genre_scores_gemma":[0.9885843,0.007235137,0.0009839541,0.00008357008,0.00007388931,0.0000129524,0.0000820347,0.000005389469,0.002938878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155174,"threshold_uncertainty_score":0.003864408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009896249206491481,"score_gpt":0.271422059808011,"score_spread":0.2615258106015195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}