{"id":"W4200463735","doi":"10.1053/j.gastro.2021.11.037","title":"The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Cancer Council Tasmania; Cancer Council South Australia; Medical Research Council; Department of Health and Aged Care, Australian Government; Core Research for Evolutional Science and Technology; Ministry of Education, Culture, Sports, Science and Technology; Wellcome Trust; Lions Medical Research Foundation; Australian Government; Government of South Australia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Japan Agency for Medical Research and Development; Takeda Science Foundation","keywords":"Stromal cell; Cancer research; Biology; Carcinogenesis; Colorectal cancer; Cancer-Associated Fibroblasts; Cancer; Tumor microenvironment; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336832,0.00006606407,0.0002502009,0.00003259558,0.00003010862,0.000003505633,0.00002663753,0.00004389458,0.00002764697],"category_scores_gemma":[0.00007543927,0.00005066176,0.00004483078,0.0001039402,0.00009913049,0.00001214113,0.00003415681,0.00007969745,4.389655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008520141,"about_ca_system_score_gemma":0.00008221707,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006427577,"about_ca_topic_score_gemma":0.02165246,"domain_scores_codex":[0.9992817,0.0000900641,0.0001867452,0.0001389521,0.00007423492,0.0002283059],"domain_scores_gemma":[0.9996365,0.0000530429,0.00007211652,0.00007860958,0.0001120451,0.00004768252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008790067,0.00006247347,0.9166805,0.00001455591,0.00008444813,0.00002967025,0.00005171099,0.000007014891,0.0801252,0.00004569021,0.0001617702,0.00185794],"study_design_scores_gemma":[0.002888688,0.000469586,0.948594,0.00004185037,0.00008437343,0.00005125903,0.00006555114,0.00005409596,0.04668336,0.00002208963,0.001019705,0.00002544799],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963346,0.00165693,0.00001740141,0.001660441,0.0001473093,0.0001142112,0.00003387167,0.000005680053,0.0000296295],"genre_scores_gemma":[0.9986855,0.0009869643,0.00003041911,0.0001735149,0.00002696373,0.00002296332,0.0000208417,0.000005454533,0.000047428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03344185,"threshold_uncertainty_score":0.9961998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009896249206491481,"score_gpt":0.271422059808011,"score_spread":0.2615258106015195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}