{"id":"W4200468018","doi":"10.1186/s12866-021-02410-z","title":"Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants","year":2021,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Kyungpook National University; Scheme for Promotion of Academic and Research Collaboration; Banting Research Foundation; Natural Sciences and Engineering Research Council of Canada; McMaster University; University of Guelph","keywords":"Cryptococcus neoformans; Biology; Virulence; Proteome; Cryptococcosis; Microbiology; Zinc; Proteomics; Melanin; Fungal protein; Genetics; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009649921,0.0003340225,0.0002126427,0.0004613272,0.000178647,0.0002938992,0.0001421125,0.0002920333,0.0005208044],"category_scores_gemma":[0.0001227385,0.00009116228,0.0002533152,0.0004160031,0.0001781919,0.0001841598,0.0002438277,0.0002623111,0.0001885251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585661,"about_ca_system_score_gemma":0.0001892646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432402,"about_ca_topic_score_gemma":0.001671732,"domain_scores_codex":[0.9999205,0.000004284971,0.000005185339,0.00002429626,0.00002598606,0.00001970934],"domain_scores_gemma":[0.9999206,0.000009105033,0.00002829894,0.000007325148,0.00001375762,0.00002095367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494649,0.00001272405,0.001935857,0.0000263131,0.000004778095,0.00008535852,0.00001737738,0.00004379447,0.9967534,0.00001960667,0.00003585346,0.0009154576],"study_design_scores_gemma":[0.00001535123,0.0002246518,0.2527474,0.00002161705,0.00004572762,0.001156222,0.0002457134,0.003697842,0.7391528,0.0002290434,0.002444598,0.00001900946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951912,0.0004341378,0.0008307812,0.00008315036,0.00001225865,0.00001648013,0.00294576,0.00003778598,0.0004484435],"genre_scores_gemma":[0.99224,0.0004784995,0.002467698,0.00007853036,0.000008378121,0.00002292511,0.003416343,0.00001514145,0.001272546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432402,"threshold_uncertainty_score":0.002848148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974791176350764,"score_gpt":0.2944348392296243,"score_spread":0.2746869274661167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}