{"id":"W4200468018","doi":"10.1186/s12866-021-02410-z","title":"Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants","year":2021,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Kyungpook National University; Scheme for Promotion of Academic and Research Collaboration; Banting Research Foundation; Natural Sciences and Engineering Research Council of Canada; McMaster University; University of Guelph","keywords":"Cryptococcus neoformans; Biology; Virulence; Proteome; Cryptococcosis; Microbiology; Zinc; Proteomics; Melanin; Fungal protein; Genetics; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659939,0.0001135194,0.0004352128,0.0001043028,0.00004272296,0.00000433523,0.0000470047,0.0001159175,0.0001187506],"category_scores_gemma":[0.0003583414,0.00009472804,0.00006020125,0.000208552,0.0003555396,0.00006131081,0.0001334413,0.0001395771,0.00001053334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000321464,"about_ca_system_score_gemma":0.0001898271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001967379,"about_ca_topic_score_gemma":0.0005976083,"domain_scores_codex":[0.9989836,0.00008319054,0.0004380903,0.0002513751,0.00003773709,0.0002059729],"domain_scores_gemma":[0.9993256,0.0001105243,0.0001232547,0.0002073278,0.0002018721,0.00003146074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008168578,0.00006271106,0.4494538,0.0004410594,0.00001343735,0.000009304028,0.0002725029,0.000001676551,0.5495836,0.0000180844,0.000006858595,0.00005529133],"study_design_scores_gemma":[0.000602102,0.0002500913,0.3525375,0.0001787855,0.00002446368,0.0002119534,0.000419658,0.00001874465,0.6455095,0.00008386237,0.00008549624,0.00007776552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982949,0.0007966285,0.00002086252,0.00002165711,0.00009301597,0.0004993535,0.00004447656,0.00001064306,0.0002184975],"genre_scores_gemma":[0.9985595,0.0001020198,0.001012111,0.00003085345,0.00001623602,0.00005489707,0.000008843668,0.000006243723,0.0002093129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09691628,"threshold_uncertainty_score":0.3862897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974791176350764,"score_gpt":0.2944348392296243,"score_spread":0.2746869274661167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}