{"id":"W4200468047","doi":"10.1158/1535-7163.targ-21-cc04-01","title":"Abstract CC04-01: First-in-human biomarker-driven phase I TRESR trial of ataxia telangiectasia and Rad3-related inhibitor (ATRi) RP-3500 in patients (pts) with advanced solid tumors harboring synthetic lethal (SL) genomic alterations","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Zygosity; Germline; Medicine; Internal medicine; Neutropenia; Biomarker; Cancer research; Oncology; Biology; Genetics; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008458913,0.000252782,0.0003068326,0.0001154369,0.00005624197,0.00002645817,0.0001255564,0.0001405171,0.0000151239],"category_scores_gemma":[0.00001337117,0.0002601735,0.00008449062,0.0001984716,0.0000706397,0.000008866859,0.0000621891,0.0001607181,4.484817e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006669772,"about_ca_system_score_gemma":0.0001136941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004652304,"about_ca_topic_score_gemma":0.0002405665,"domain_scores_codex":[0.9985775,0.00005301725,0.00045366,0.0004417712,0.0001642207,0.0003098791],"domain_scores_gemma":[0.9993803,0.00001427901,0.000127739,0.0003438673,0.00006247373,0.00007135644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001662736,0.000419903,0.003024739,0.00006581814,0.0001710031,0.00005980245,0.0002092764,0.01066162,0.9772184,0.000007142751,0.000002868551,0.00649673],"study_design_scores_gemma":[0.0439392,0.001046834,0.01863842,0.0002674503,0.0001178093,0.00001108182,0.00008539345,0.001325763,0.9331492,0.00001535555,0.0008773998,0.0005260945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952192,0.003427054,0.0005715316,0.00005916793,0.0001365536,0.0004637058,0.00005833111,0.00001052945,0.0000538754],"genre_scores_gemma":[0.9989832,0.0003646431,0.0003137328,0.00003503934,0.00004129476,0.00006111917,0.0001319399,0.00005376376,0.00001523312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04406916,"threshold_uncertainty_score":0.999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023200997589636,"score_gpt":0.302696885009439,"score_spread":0.2924648750335427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}