{"id":"W4200468047","doi":"10.1158/1535-7163.targ-21-cc04-01","title":"Abstract CC04-01: First-in-human biomarker-driven phase I TRESR trial of ataxia telangiectasia and Rad3-related inhibitor (ATRi) RP-3500 in patients (pts) with advanced solid tumors harboring synthetic lethal (SL) genomic alterations","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Zygosity; Germline; Medicine; Internal medicine; Neutropenia; Biomarker; Cancer research; Oncology; Biology; Genetics; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005659981,0.0009778575,0.0007739835,0.0003088971,0.000272429,0.0006807048,0.0005094621,0.000722907,0.005917001],"category_scores_gemma":[0.0003857742,0.000259799,0.0004625597,0.0002583515,0.0004156683,0.0003595983,0.0002676902,0.001349165,0.001103131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008857386,"about_ca_system_score_gemma":0.0009715067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008545471,"about_ca_topic_score_gemma":0.002608316,"domain_scores_codex":[0.9998019,0.00007210001,0.000009609815,0.00004113247,0.00002528463,0.00004993584],"domain_scores_gemma":[0.9997613,0.00002359453,0.00004354041,0.00001802298,0.00001759142,0.0001359211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4806394,0.04391123,0.0189339,0.001233225,0.001369578,0.0007681898,0.0003718759,0.00590998,0.2485105,0.000855762,0.01522924,0.1822671],"study_design_scores_gemma":[0.2414735,0.6856776,0.03650537,0.00008148851,0.0007003354,0.001307269,0.0001118694,0.002976458,0.02016575,0.0003508399,0.01058749,0.00006205873],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928543,0.0008707574,0.0004371325,0.0002745191,0.00004262913,0.001326819,0.001796636,0.0001685592,0.002228715],"genre_scores_gemma":[0.9878131,0.0005402477,0.001390479,0.0005881675,0.0000664754,0.001313381,0.003748452,0.00004224402,0.0044974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005917001,"threshold_uncertainty_score":0.0197944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023200997589636,"score_gpt":0.302696885009439,"score_spread":0.2924648750335427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}