{"id":"W4200480175","doi":"10.3390/cells11010029","title":"Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Medicine; Apolipoprotein B; Alzheimer's disease; Disease; Internal medicine; Endocrinology; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006137114,0.0003353672,0.00036144,0.0006510637,0.0002571072,0.0005351232,0.0002122876,0.0002326318,0.00132584],"category_scores_gemma":[0.00184825,0.0001602207,0.0005202643,0.001328689,0.0001546768,0.0002117387,0.0003481866,0.0006371254,0.00017775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001750802,"about_ca_system_score_gemma":0.000210312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003688613,"about_ca_topic_score_gemma":0.004051919,"domain_scores_codex":[0.999476,0.0001178306,0.00007576113,0.0001513425,0.0001190192,0.00006000765],"domain_scores_gemma":[0.9987918,0.0002184853,0.0005785004,0.00013419,0.0001527671,0.0001243192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001944163,0.00002484993,0.9949002,0.00003022513,0.0002662109,0.00005531525,0.00002588974,0.00009312571,0.0005098624,0.00003660367,0.0002597626,0.003603583],"study_design_scores_gemma":[0.000003747605,0.0000266928,0.9987571,0.000004675134,0.00008716748,0.0001835981,0.00002480527,0.0003786527,0.0001288189,0.00009040881,0.0003115125,0.000002892268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945357,0.001920215,0.0004660225,0.0001362038,0.00002673592,0.000006841091,0.002054373,0.00001753378,0.0008363551],"genre_scores_gemma":[0.9974968,0.0004189265,0.0003388053,0.00002759754,0.00002805918,0.000005923522,0.00138902,0.000003600388,0.0002912838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003688613,"threshold_uncertainty_score":0.007334292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239592482758423,"score_gpt":0.2622886751093141,"score_spread":0.2298927502817299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}