{"id":"W4200480175","doi":"10.3390/cells11010029","title":"Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Medicine; Apolipoprotein B; Alzheimer's disease; Disease; Internal medicine; Endocrinology; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008021611,0.0001853722,0.0004908476,0.00005960517,0.00009243849,0.00002347852,0.0000329212,0.000050852,0.00005724057],"category_scores_gemma":[0.0001388376,0.0001464417,0.0001770515,0.0001734292,0.0002004076,0.00007743428,0.00007568988,0.00008912523,0.000004713186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000224678,"about_ca_system_score_gemma":0.000282121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004978931,"about_ca_topic_score_gemma":0.000007074758,"domain_scores_codex":[0.9986112,0.00009514846,0.0001644858,0.0003816199,0.0004351271,0.0003124843],"domain_scores_gemma":[0.9985059,0.00007551815,0.00007289526,0.0003766453,0.0002520131,0.0007169634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001333445,0.002445403,0.8222442,0.0008147776,0.1355251,0.015846,0.0003943395,0.00003384123,0.00481932,0.00006665965,0.0009798241,0.01549705],"study_design_scores_gemma":[0.003843972,0.0001894301,0.9395712,0.0006372226,0.0106366,0.00003633269,0.00021054,0.0001713714,0.04427132,0.00008570277,0.00009800832,0.0002482859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8402621,0.1585478,0.00001341185,0.0002148716,0.00001928784,0.0004363617,0.0003793,0.00003352709,0.00009329811],"genre_scores_gemma":[0.9991442,0.0004522908,0.00009246692,0.0000992952,0.00004960306,0.00001618389,0.00006735074,0.00003055567,0.00004805941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588821,"threshold_uncertainty_score":0.5971718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239592482758423,"score_gpt":0.2622886751093141,"score_spread":0.2298927502817299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}