{"id":"W4200480616","doi":"10.1158/2159-8290.cd-21-1225","title":"Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Chromatin; Mitochondrial DNA; DNA; DNA sequencing; Mutation; Somatic evolution in cancer; Deep sequencing; Selection (genetic algorithm)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002061682,0.0004013111,0.0004089185,0.0009594228,0.0005465319,0.00256105,0.000640934,0.00148444,0.002040841],"category_scores_gemma":[0.002101577,0.0004108585,0.0004251905,0.0004030057,0.001201376,0.001104229,0.001161606,0.002973777,0.0007443513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005020231,"about_ca_system_score_gemma":0.0004006324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930743,"about_ca_topic_score_gemma":0.001368023,"domain_scores_codex":[0.9990399,0.0001389677,0.0000974658,0.0002062505,0.000385434,0.0001320383],"domain_scores_gemma":[0.9985213,0.0005905576,0.0002500576,0.0001432359,0.0002698605,0.0002250406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001178358,0.0004317652,0.03105671,0.0006134202,0.0002565857,0.002474821,0.001119995,0.001117564,0.2957403,0.00974009,0.2828632,0.3734072],"study_design_scores_gemma":[0.0004321044,0.001531739,0.03834467,0.0003429741,0.0005460769,0.00694255,0.001636011,0.00977086,0.2344704,0.01225051,0.693545,0.0001871077],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4537857,0.06835115,0.0523602,0.2966728,0.08965176,0.0005707431,0.002563418,0.002808401,0.03323591],"genre_scores_gemma":[0.7389048,0.0527909,0.02364716,0.074755,0.07009006,0.0003471607,0.001236418,0.0007220028,0.03750651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00256105,"threshold_uncertainty_score":0.01090336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511958589279313,"score_gpt":0.3446364575280078,"score_spread":0.3195168716352146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}