{"id":"W4200483104","doi":"10.1101/2021.12.14.472657","title":"Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza Virus","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Research Manitoba","keywords":"Virology; Bivalent (engine); Biology; Vaccination; Virus; Ebola vaccine; Immune system; Influenza vaccine; Ectodomain; Vesicular stomatitis virus; Antibody; Immunology; Ebola virus; Receptor; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168092,0.0003414084,0.0001963649,0.0001507041,0.00007356489,0.0001941969,0.0001615173,0.0002383875,0.0003588866],"category_scores_gemma":[0.0001460307,0.0001108312,0.0002768729,0.00009413125,0.00009419061,0.0001364744,0.0001508345,0.000308566,0.000220596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001843005,"about_ca_system_score_gemma":0.000148511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004733433,"about_ca_topic_score_gemma":0.0004137478,"domain_scores_codex":[0.9999069,0.00001178333,0.00001125896,0.00001977786,0.00003002619,0.00002029691],"domain_scores_gemma":[0.999941,0.000007098291,0.00001534527,0.000007005811,0.00001604735,0.00001340272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003044972,0.00003176877,0.0004178853,0.00001826249,0.000004192892,0.000021832,0.000007842189,0.0001326306,0.9983785,0.00003292214,0.00001717514,0.0009065167],"study_design_scores_gemma":[0.00004403224,0.0017354,0.009418231,0.00001066174,0.00006239924,0.0003932156,0.00004365584,0.003541827,0.9801176,0.00005945937,0.00456616,0.000007296945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993299,0.0005734465,0.005228196,0.00004298661,0.00002616386,0.0000660335,0.0002090329,0.00002267375,0.00053254],"genre_scores_gemma":[0.9911199,0.0003435348,0.005144638,0.00005868528,0.000009464616,0.0000472375,0.001722095,0.00001429353,0.001540173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004733433,"threshold_uncertainty_score":0.001337171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725374174875821,"score_gpt":0.2746391973736551,"score_spread":0.2473854556248969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}