{"id":"W4200488061","doi":"10.3390/vaccines10010014","title":"The Signal Peptide and Chaperone UNC93B1 Both Influence TLR8 Ectodomain Intracellular Endosomal Localization","year":2021,"lang":"en","type":"article","venue":"Vaccines","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"Ectodomain; Endosome; Cell biology; Intracellular; Biology; Innate immune system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416229,0.0001199975,0.0001339732,0.0000396673,0.0004246978,0.00004901936,0.00009774973,0.0001173671,0.0002009386],"category_scores_gemma":[0.0001910968,0.0000865572,0.0000336354,0.0001375745,0.0000677514,0.0001610517,0.00007439286,0.0001311926,0.0001230433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000158757,"about_ca_system_score_gemma":0.0000621706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003732655,"about_ca_topic_score_gemma":0.00004625084,"domain_scores_codex":[0.9990646,0.0002544212,0.0002356345,0.0001852053,0.00003104801,0.0002291111],"domain_scores_gemma":[0.9993699,0.0002474549,0.00007929933,0.0001938089,0.00009626601,0.00001329509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002212723,0.00002442339,0.002865601,0.00001371292,0.00006719777,0.00001348948,0.0003104863,0.000102271,0.9841182,0.002789769,0.001112194,0.008361413],"study_design_scores_gemma":[0.001125471,0.000104013,0.0365799,0.00003805965,0.00003596397,0.0002362755,0.0004099515,0.0001966499,0.8080459,0.0004799522,0.1525676,0.0001802334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841806,0.01329509,0.001071025,0.0008577995,0.0001880663,0.0001192959,0.00000204689,0.00004701108,0.0002391085],"genre_scores_gemma":[0.9955852,0.001045182,0.00003566059,0.0001408148,0.00004524193,0.00001426201,0.00005837639,0.00001113134,0.00306413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1760723,"threshold_uncertainty_score":0.35297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004880369838693835,"score_gpt":0.1993773479510295,"score_spread":0.1944969781123356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}