{"id":"W4200488061","doi":"10.3390/vaccines10010014","title":"The Signal Peptide and Chaperone UNC93B1 Both Influence TLR8 Ectodomain Intracellular Endosomal Localization","year":2021,"lang":"en","type":"article","venue":"Vaccines","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"Ectodomain; Endosome; Cell biology; Intracellular; Biology; Innate immune system; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071109,0.0002582968,0.0002313485,0.0001215393,0.0001826388,0.0003323193,0.0001268478,0.0002810294,0.001737334],"category_scores_gemma":[0.0002557137,0.0001168056,0.000174159,0.0001179285,0.0001896037,0.0002598237,0.0002589402,0.000457156,0.0004902481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110096,"about_ca_system_score_gemma":0.0001331069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005540868,"about_ca_topic_score_gemma":0.0005340216,"domain_scores_codex":[0.9998378,0.00003263202,0.00001157512,0.00002483863,0.00003113677,0.00006208618],"domain_scores_gemma":[0.9998862,0.00002486541,0.00003539902,0.000009723606,0.00001497006,0.00002885213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004699974,0.0000508381,0.0003246861,0.00006620769,0.000009838474,0.00006550016,0.00001877701,0.00009548485,0.9964427,0.00008507027,0.0001951824,0.002175519],"study_design_scores_gemma":[0.00005558467,0.0005503682,0.01199822,0.00002398585,0.00004659188,0.0003225124,0.000123654,0.001752223,0.9788649,0.0001660446,0.006077707,0.00001827999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945561,0.002441943,0.0008387282,0.0001703593,0.00005789178,0.00001078661,0.0002329204,0.00005340911,0.001637893],"genre_scores_gemma":[0.9972526,0.0007138017,0.0005533377,0.0001513995,0.000009229919,0.00001386774,0.0003139881,0.00001839547,0.0009733028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737334,"threshold_uncertainty_score":0.00581193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004880369838693835,"score_gpt":0.1993773479510295,"score_spread":0.1944969781123356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}