{"id":"W4200494608","doi":"10.3390/cells11010022","title":"Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McGill University; St. Joseph’s Healthcare Hamilton; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; COPD; Downregulation and upregulation; Flow cytometry; Messenger RNA; Lung; Immunology; Biology; Molecular biology; Receptor; Medicine; Cell culture; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576515,0.0001936185,0.0002074641,0.0001658802,0.0002248666,0.0004663693,0.00008903193,0.0002159138,0.001080277],"category_scores_gemma":[0.0001714662,0.0001140192,0.0002924535,0.0000930781,0.0002219241,0.0001409566,0.0001801436,0.0002673209,0.0003566769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139661,"about_ca_system_score_gemma":0.0001578861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000429438,"about_ca_topic_score_gemma":0.0007151305,"domain_scores_codex":[0.9998312,0.00003595193,0.00001263285,0.00004372907,0.00003361327,0.00004284067],"domain_scores_gemma":[0.9998802,0.00002253042,0.00004277529,0.0000110831,0.00001705405,0.00002632167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004036945,0.00003944721,0.01103092,0.00008098791,0.00003249376,0.0005153627,0.00006102035,0.0001922888,0.9810424,0.0002353526,0.000206165,0.006159808],"study_design_scores_gemma":[0.00004486818,0.0007953651,0.2971263,0.00004355355,0.0001212933,0.002439211,0.0004225257,0.004601709,0.687288,0.0005416114,0.006551103,0.00002451737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990507,0.004849313,0.002153157,0.0002898239,0.00004171412,0.00001696572,0.0002638179,0.00006460724,0.001813647],"genre_scores_gemma":[0.9967147,0.0008401298,0.000879587,0.0001072372,0.00001756636,0.00001009837,0.0001565082,0.00001018078,0.001264038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080277,"threshold_uncertainty_score":0.003613889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007316774176705,"score_gpt":0.2656390189141914,"score_spread":0.2555658511724244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}