{"id":"W4200497292","doi":"10.1152/ajpgi.00160.2021","title":"Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota","year":2021,"lang":"en","type":"review","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada; Crohn's and Colitis Canada; University of Calgary","keywords":"Pregnane X receptor; Aryl hydrocarbon receptor; Xenobiotic; Receptor; Biology; Immune system; Homeostasis; Cell biology; Catabolism; Intestinal mucosa; Gastrointestinal tract; Microbiology; Biochemistry; Nuclear receptor; Metabolism; Immunology; Enzyme; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223298,0.0005857786,0.0008453529,0.00165465,0.00018618,0.0008039775,0.0004656632,0.0006729907,0.00396801],"category_scores_gemma":[0.0002668597,0.0001650497,0.0003261284,0.001499461,0.0002216477,0.0008088271,0.0005084869,0.00114374,0.002744806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003240711,"about_ca_system_score_gemma":0.0006127856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005297104,"about_ca_topic_score_gemma":0.001083068,"domain_scores_codex":[0.9999185,0.0000137191,0.00001023812,0.00001444076,0.00003256781,0.00001057578],"domain_scores_gemma":[0.999916,0.00003233792,0.00001274187,0.000003181938,0.00002407993,0.00001173567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007725221,0.0001000557,0.0001900573,0.01337276,0.00008167906,0.0002440464,0.00006931482,0.0003586326,0.005083689,0.004557278,0.0209037,0.9549616],"study_design_scores_gemma":[0.00001122927,0.0001300099,0.0007981982,0.001771013,0.00007066243,0.00104237,0.00005417851,0.00008119603,0.0008686499,0.001769024,0.993389,0.00001437147],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002483874,0.997591,0.0001809585,0.000196345,0.000151197,0.000005478995,0.00002859858,0.00001021584,0.001587804],"genre_scores_gemma":[0.0007823013,0.99795,0.0001732376,0.0001107044,0.00008836052,0.000006064459,0.00003522319,0.000001325951,0.0008526927],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00396801,"threshold_uncertainty_score":0.01327431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05225644261763122,"score_gpt":0.3512901231364465,"score_spread":0.2990336805188152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}