{"id":"W4200499102","doi":"10.1038/s41598-021-03220-z","title":"Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Indiana Retired Teachers Association; Centres de Recerca de Catalunya; European Social Fund; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria","keywords":"Antimicrobial; Recombinant DNA; Antimicrobial peptides; Biology; Klebsiella pneumoniae; Beta defensin; Innate immune system; Immune system; Function (biology); Defensin; Microbiology; Escherichia coli; Computational biology; Cell biology; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002435382,0.0002469398,0.0001718437,0.0001349688,0.00007156654,0.0002522435,0.0001852961,0.0002262259,0.0007822776],"category_scores_gemma":[0.0002107833,0.0001125278,0.0002009007,0.0001251593,0.000160879,0.0002223373,0.0001775034,0.000464491,0.0002680256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001469244,"about_ca_system_score_gemma":0.00006316724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005466393,"about_ca_topic_score_gemma":0.00007558607,"domain_scores_codex":[0.9998831,0.00002727122,0.00001358633,0.00002510886,0.00002910111,0.00002192376],"domain_scores_gemma":[0.9998052,0.0000517368,0.00006269282,0.00002509039,0.00001875302,0.00003664737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004809367,0.00001237363,0.00004882425,0.00001288037,0.000002266077,0.00001502949,0.000003796854,0.00004227583,0.9993374,0.0000277022,0.000006480304,0.000442893],"study_design_scores_gemma":[0.00001213909,0.000202033,0.0009194872,0.000003301394,0.00001487868,0.0001948532,0.000007540005,0.0007885165,0.9963223,0.00002214377,0.001509143,0.000003759865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946203,0.0005822672,0.004224322,0.00003725936,0.00002106596,0.00001570521,0.00007072365,0.00003420925,0.0003941681],"genre_scores_gemma":[0.9896467,0.0003871509,0.0084282,0.00004795614,0.00001415077,0.00002608643,0.0003104295,0.00003472807,0.001104485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007822776,"threshold_uncertainty_score":0.002617002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285981681905727,"score_gpt":0.2322169430027836,"score_spread":0.2036187748122109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}