{"id":"W4200500548","doi":"10.1016/j.exer.2021.108902","title":"Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases","year":2021,"lang":"en","type":"article","venue":"Experimental Eye Research","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; Foundation Fighting Blindness","keywords":"Nitric oxide synthase; Cystathionine beta synthase; Retinal degeneration; Reactive oxygen species; Nitric oxide; Biology; Biochemistry; Oxidative stress; Transsulfuration; Cell biology; GPX4; Lipid peroxidation; Retinal; Chemistry; Superoxide dismutase; Enzyme; Glutathione peroxidase; Endocrinology; Cysteine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002593538,0.0003767162,0.0002150835,0.0009348682,0.0001922999,0.0003562412,0.0002471195,0.0004299975,0.001104385],"category_scores_gemma":[0.000279679,0.0001562064,0.0001865576,0.0004997636,0.0004502587,0.0002738425,0.000282744,0.0003422566,0.00008390454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004259883,"about_ca_system_score_gemma":0.0002627639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00182045,"about_ca_topic_score_gemma":0.001710404,"domain_scores_codex":[0.9998552,0.00003725923,0.00002350206,0.00003143382,0.00003184927,0.00002081345],"domain_scores_gemma":[0.9998135,0.00003135341,0.00008794363,0.00001534603,0.00002187548,0.00002995621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004159363,0.0001428985,0.0417157,0.0001962265,0.0001879034,0.00318699,0.0002491705,0.000382189,0.9269652,0.003069359,0.0003471074,0.0193979],"study_design_scores_gemma":[0.0001297538,0.0006274479,0.3663685,0.0000583922,0.0003618971,0.00887079,0.0007455368,0.002626157,0.6105158,0.004318471,0.005344728,0.00003255413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909657,0.006702475,0.001020353,0.0001950126,0.00002008193,0.000005077579,0.0002013635,0.00002493104,0.0008650071],"genre_scores_gemma":[0.9960088,0.002227216,0.0006807158,0.00003787289,0.00001127937,0.000004602532,0.0001004279,0.000006086629,0.0009229869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182045,"threshold_uncertainty_score":0.003694534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04440083003885628,"score_gpt":0.3735872582779446,"score_spread":0.3291864282390884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}