{"id":"W4200500658","doi":"10.3390/cancers14010099","title":"Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Rivkin Center for Ovarian Cancer","keywords":"Cancer research; Unfolded protein response; Nelfinavir; DNA damage; Programmed cell death; Pharmacology; Medicine; Apoptosis; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009941109,0.0002216409,0.0002262529,0.0001414099,0.0001160941,0.0001630937,0.00008261202,0.0001798556,0.0006507149],"category_scores_gemma":[0.000100203,0.00007321119,0.0001923958,0.0001167473,0.0001072268,0.0001164963,0.0001052673,0.0002402781,0.0001028443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001309271,"about_ca_system_score_gemma":0.0001020652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003347209,"about_ca_topic_score_gemma":0.0005927088,"domain_scores_codex":[0.9999006,0.00002587712,0.00001400275,0.00001287907,0.00002447293,0.00002231411],"domain_scores_gemma":[0.9999462,0.00001342305,0.00001184596,0.00001067156,0.000008100748,0.000009701588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003650264,0.0001034114,0.0008149013,0.00007796388,0.00001257293,0.00008062158,0.00002480968,0.00007603006,0.9944982,0.00004236245,0.00005041986,0.003853771],"study_design_scores_gemma":[0.00003334593,0.00171735,0.01579858,0.00000755163,0.00001664466,0.0006910653,0.00003760922,0.0005279022,0.9790677,0.00003408791,0.002063819,0.000004271866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966413,0.001958799,0.000455703,0.00002487668,0.00001823113,0.00001626063,0.000167826,0.00001726887,0.0006997542],"genre_scores_gemma":[0.997598,0.0008587463,0.0004651983,0.00002237176,0.000007493937,0.00001537848,0.0003369041,0.000002901178,0.0006929986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006507149,"threshold_uncertainty_score":0.002176821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491512700718638,"score_gpt":0.243531927849012,"score_spread":0.2286168008418256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}