{"id":"W4200500658","doi":"10.3390/cancers14010099","title":"Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Rivkin Center for Ovarian Cancer","keywords":"Cancer research; Unfolded protein response; Nelfinavir; DNA damage; Programmed cell death; Pharmacology; Medicine; Apoptosis; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004757348,0.000230043,0.0004981123,0.0001356028,0.0001305824,0.00001777047,0.00008558799,0.0002693334,0.00003888178],"category_scores_gemma":[0.0003877358,0.0002032325,0.0001204437,0.0007868181,0.0001892976,0.0002812362,0.0000612161,0.0002454917,1.225521e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001460052,"about_ca_system_score_gemma":0.002161296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006539281,"about_ca_topic_score_gemma":0.0005192064,"domain_scores_codex":[0.9977815,0.0004078346,0.0005923022,0.0003842615,0.0005584173,0.0002757114],"domain_scores_gemma":[0.9983117,0.00002737267,0.0008619198,0.0003212727,0.0003688774,0.0001088317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000977613,0.0001638312,0.001809504,0.0005560846,0.0001388375,0.000002312723,0.0006699291,0.0005173481,0.9936728,0.00004138259,0.00008403215,0.001366254],"study_design_scores_gemma":[0.002145819,0.0002757438,0.135009,0.001004932,0.000138916,0.0000014537,0.0008043227,0.0004035062,0.8598246,0.0002282468,0.00000639361,0.0001571151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957248,0.0004405025,0.00006532172,0.001230761,0.0001134034,0.002129686,0.0002441734,0.00003016707,0.00002115899],"genre_scores_gemma":[0.9991041,0.00009848389,0.0001464256,0.00007097596,0.00004481114,0.0003786426,0.00004057967,0.00003063388,0.00008528426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338483,"threshold_uncertainty_score":0.9885481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491512700718638,"score_gpt":0.243531927849012,"score_spread":0.2286168008418256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}