{"id":"W4200501239","doi":"10.1016/j.ccell.2021.12.006","title":"Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":414,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; National Key Research and Development Program of China; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences; Science and Technology Commission of Shanghai Municipality; Fudan University; National Natural Science Foundation of China; Shanghai Municipal Health Commission","keywords":"KRAS; Pathogenesis; Cancer research; Proteogenomics; Biology; Intrahepatic Cholangiocarcinoma; Metastasis; Signal transduction; Transcriptome; Computational biology; Mutation; Cancer; Gene; Medicine; Immunology; Pathology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354303,0.0001747281,0.0004815057,0.0000461891,0.00005862206,0.00002139424,0.00009573054,0.00009133697,0.0004657372],"category_scores_gemma":[0.00006095196,0.0001624631,0.0002012335,0.0002051011,0.0000894163,0.00009927467,0.00008370001,0.0001557827,0.00002585974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014959,"about_ca_system_score_gemma":0.0003522799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001420983,"about_ca_topic_score_gemma":0.00009794599,"domain_scores_codex":[0.9985306,0.00004806105,0.0005619458,0.0003773569,0.000235741,0.0002462506],"domain_scores_gemma":[0.9988856,0.00004557947,0.0002239428,0.0004163824,0.0003222843,0.0001062431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002111232,0.0001790102,0.3321561,0.0007086489,0.0001493962,0.00008369229,0.001229486,8.043254e-7,0.660787,0.00003071345,0.0003835862,0.004080447],"study_design_scores_gemma":[0.001472947,0.0001998888,0.7320117,0.0002282931,0.0003101186,0.00002644858,0.0003172837,0.00004782335,0.2633041,0.00004880533,0.001842917,0.0001896734],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866171,0.008298774,0.0001249762,0.0006343085,0.0005334977,0.0004219766,0.0000501373,0.00004184784,0.003277352],"genre_scores_gemma":[0.9930471,0.003297889,0.0002646261,0.000480043,0.0003795405,0.0001043501,0.0001358546,0.00003480848,0.002255748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3998556,"threshold_uncertainty_score":0.6625053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064029640178111,"score_gpt":0.2776578269147729,"score_spread":0.2570175305129918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}