{"id":"W4200502803","doi":"10.1080/10428194.2021.2012667","title":"Phase I trials of the lysine-specific demethylase 1 inhibitor, GSK2879552, as mono- and combination-therapy in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes","year":2021,"lang":"en","type":"letter","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myelodysplastic syndromes; Myeloid leukemia; Refractory (planetary science); Demethylase; Medicine; Internal medicine; Leukemia; Oncology; Cancer research; Biology; Gene; Bone marrow; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008462907,0.0003601742,0.0006633069,0.0001817881,0.0004857208,0.0007348827,0.0005749818,0.005496797,0.002794807],"category_scores_gemma":[0.001491691,0.0001707596,0.0004539404,0.0001995308,0.0004363853,0.0005791851,0.0002046518,0.003585784,0.00106842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00114356,"about_ca_system_score_gemma":0.0006683259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008546676,"about_ca_topic_score_gemma":0.003944352,"domain_scores_codex":[0.9997017,0.0001086047,0.00002864821,0.00003769782,0.00007112029,0.0000522717],"domain_scores_gemma":[0.999308,0.0003618675,0.00006463045,0.00002151059,0.0000508782,0.0001930693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01356292,0.00139659,0.006838397,0.0003700501,0.0002049057,0.01246836,0.0001526583,0.001340453,0.01067519,0.004768517,0.7373028,0.2109191],"study_design_scores_gemma":[0.03677149,0.01129167,0.02324497,0.0003990065,0.0004165596,0.0178001,0.000315517,0.008161271,0.01020435,0.01993928,0.8713505,0.0001053401],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.09135918,0.02006202,0.001234534,0.8152573,0.02724248,0.0004792268,0.001960708,0.0002316393,0.04217293],"genre_scores_gemma":[0.2881004,0.01147023,0.0025871,0.6107455,0.03316394,0.0006727049,0.00149177,0.00009675304,0.05167152],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005496797,"threshold_uncertainty_score":0.009349525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0207334440900831,"score_gpt":0.2678499167161682,"score_spread":0.2471164726260851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}