{"id":"W4200504528","doi":"10.1158/1535-7163.mct-21-0615","title":"RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors","year":2021,"lang":"en","type":"letter","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cégep de Saint-Laurent; Telesta Therapeutics (Canada); Aegera Therapeutics (Canada)","funders":"","keywords":"Kinase; Olaparib; Pharmacology; In vivo; DNA damage; PARP inhibitor; PI3K/AKT/mTOR pathway; Cancer research; Chemistry; Biology; Biochemistry; Signal transduction; DNA; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257321,0.0007816066,0.0004871835,0.0004994927,0.0001455314,0.0003520612,0.0005685065,0.0004338349,0.00213604],"category_scores_gemma":[0.00009581527,0.0002605774,0.0002761329,0.000266656,0.0002418299,0.0003858947,0.0001509688,0.0009270501,0.0006746417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000327509,"about_ca_system_score_gemma":0.0003537563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005646349,"about_ca_topic_score_gemma":0.001502455,"domain_scores_codex":[0.9998947,0.00001868666,0.000008072177,0.00002551649,0.00002975417,0.00002309985],"domain_scores_gemma":[0.9999366,0.000006517587,0.00001802767,0.000006624102,0.000007367505,0.00002486905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001698165,0.001375921,0.0002454688,0.0002391363,0.00004458487,0.0001572393,0.00002460385,0.0008382381,0.9600377,0.0002707196,0.002253439,0.03281469],"study_design_scores_gemma":[0.001885416,0.04602975,0.008392169,0.00004561155,0.0002331487,0.00303049,0.00002889004,0.004328832,0.9096185,0.0001600067,0.0261994,0.00004774705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625723,0.01196107,0.00947498,0.0004464241,0.0001352284,0.0005402428,0.002546558,0.001952869,0.01037037],"genre_scores_gemma":[0.9768876,0.005372581,0.008042499,0.0002347327,0.00004886806,0.0002790779,0.003512963,0.00006520804,0.005556362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213604,"threshold_uncertainty_score":0.007145822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383461660618057,"score_gpt":0.3300402038009939,"score_spread":0.2862055871948133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}