{"id":"W4200504671","doi":"10.1101/2021.12.13.472426","title":"Absolute Scaling of Single-Cell Transcriptomes Reveals Pervasive Hypertranscription in Adult Stem and Progenitor Cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Biology; Stem cell; Transcriptome; Progenitor cell; Cell biology; Embryonic stem cell; Cell cycle; Chromatin; Cell; Progenitor; Adult stem cell; Somatic cell; Cellular differentiation; Computational biology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000417174,0.0002110106,0.0003655456,0.0005608615,0.0002071755,0.0006624524,0.0002334958,0.0002578498,0.001019044],"category_scores_gemma":[0.0005828653,0.0002260217,0.0002054915,0.0005604198,0.0003345065,0.0003186809,0.0003426273,0.0005745019,0.0004367176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624935,"about_ca_system_score_gemma":0.0001776281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294539,"about_ca_topic_score_gemma":0.0005638766,"domain_scores_codex":[0.9996749,0.00003409575,0.00002676382,0.0001151385,0.0001251787,0.00002388833],"domain_scores_gemma":[0.9994636,0.0001766997,0.0001140748,0.0001044883,0.00009856155,0.00004264206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001851251,0.000005750637,0.001669567,0.00002473645,0.000005775491,0.00001683211,0.00003465982,0.0003132002,0.9944636,0.0001098592,0.00003348419,0.003304037],"study_design_scores_gemma":[0.000004134542,0.0001415669,0.1111436,0.00001531865,0.00002695901,0.0002396466,0.0001510923,0.01738028,0.8676158,0.0009149757,0.002340996,0.00002561421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9249092,0.000795081,0.06976433,0.00007465338,0.00003470917,0.00005040103,0.002233334,0.0006826459,0.001455578],"genre_scores_gemma":[0.9611878,0.0004484328,0.03406373,0.00008403118,0.0000199392,0.0001203111,0.002564168,0.0002486044,0.001262966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019044,"threshold_uncertainty_score":0.003408968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406313436747815,"score_gpt":0.1966631142931573,"score_spread":0.1825999799256792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}