{"id":"W4200505409","doi":"10.3390/cancers14010108","title":"BRCA1 and Metastasis: Outcome of Defective DNA Repair","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society; Cancer Research Society","keywords":"Homologous recombination; Ovarian cancer; Breast cancer; DNA repair; Cancer research; Mutation; Metastasis; Biology; Cancer; BRCA2 Protein; Gene; Medicine; Genetics; Oncology; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457445,0.0005992776,0.0009156552,0.001580463,0.0001840162,0.0007868917,0.0005399697,0.000643028,0.002838203],"category_scores_gemma":[0.0003817302,0.0001700813,0.0003137654,0.001294398,0.0002999939,0.0007021253,0.0004662728,0.0009359029,0.001551463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005078812,"about_ca_system_score_gemma":0.0006545621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008055553,"about_ca_topic_score_gemma":0.001317234,"domain_scores_codex":[0.9998964,0.00001725932,0.00001331201,0.00001968265,0.00004173243,0.00001151824],"domain_scores_gemma":[0.999899,0.00004076693,0.00001896283,0.000003585084,0.0000264001,0.00001128952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008030446,0.00004177766,0.0004164548,0.01428267,0.00009567198,0.0004069141,0.00006126278,0.0003835206,0.003185767,0.005138405,0.03662463,0.9392826],"study_design_scores_gemma":[0.00001350469,0.00009070775,0.001840285,0.003648522,0.0001125101,0.004784368,0.00006638955,0.00009650266,0.0009742624,0.00280336,0.9855517,0.00001792404],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001229587,0.9986714,0.00006345718,0.0001446815,0.000096905,0.000001894299,0.00001833501,0.000004511487,0.0008759042],"genre_scores_gemma":[0.0008037998,0.9983742,0.00006755852,0.00007980649,0.00007485367,0.000002774182,0.00003077487,9.767313e-7,0.0005652364],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002838203,"threshold_uncertainty_score":0.009494722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04661716848342929,"score_gpt":0.361094206950893,"score_spread":0.3144770384674637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}