{"id":"W4200505409","doi":"10.3390/cancers14010108","title":"BRCA1 and Metastasis: Outcome of Defective DNA Repair","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society; Cancer Research Society","keywords":"Homologous recombination; Ovarian cancer; Breast cancer; DNA repair; Cancer research; Mutation; Metastasis; Biology; Cancer; BRCA2 Protein; Gene; Medicine; Genetics; Oncology; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563128,0.0002492719,0.0008540483,0.00006167989,0.0000338441,0.000009344986,0.0001439177,0.000248969,0.00003002359],"category_scores_gemma":[0.0001221616,0.0002324976,0.0004864815,0.000180918,0.0001380797,0.000001721931,0.000135778,0.0001274069,0.000002344383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005281647,"about_ca_system_score_gemma":0.00174109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004626362,"about_ca_topic_score_gemma":0.00008863332,"domain_scores_codex":[0.9987553,0.0000873329,0.0003867295,0.0005091004,0.00009975263,0.0001617631],"domain_scores_gemma":[0.9990435,0.00002697892,0.0002625279,0.0004973948,0.0001114209,0.0000582408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001029247,0.00001269284,0.0001247009,0.0105568,0.002882986,0.00001191162,0.00006877772,0.00005056596,0.0001373292,0.0001351674,0.01032061,0.9756882],"study_design_scores_gemma":[0.0001193572,0.00005412055,0.00000728219,0.000915537,0.0008621604,0.00002846279,0.00006232141,8.892843e-7,0.000618926,0.000005429687,0.9970976,0.0002279704],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000244543,0.9982238,0.00006192479,0.000004930626,0.0003441209,0.0002852793,0.0002239133,0.00001077794,0.0006006559],"genre_scores_gemma":[0.0002445265,0.9980579,0.0007096851,0.00005916185,0.000166376,0.0001634128,0.0001934149,0.00004601294,0.0003595014],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9867769,"threshold_uncertainty_score":0.9480975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04661716848342929,"score_gpt":0.361094206950893,"score_spread":0.3144770384674637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}