{"id":"W4200505416","doi":"10.1016/j.bbadva.2021.100032","title":"Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses","year":2021,"lang":"en","type":"article","venue":"BBA Advances","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Glycomics Network; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"HEXA; Sandhoff disease; Neurodegeneration; Gangliosidosis; Hexosaminidase; Phosphorylation; Enzyme; Biology; Biochemistry; Chemistry; Cell biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798971,0.0004143619,0.0004255057,0.0002565354,0.0001438995,0.0004885964,0.0002462838,0.0003303971,0.001352743],"category_scores_gemma":[0.000148178,0.0001211662,0.0002810061,0.0001750685,0.0001951435,0.0003756385,0.0003526505,0.0004076798,0.0003758703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681543,"about_ca_system_score_gemma":0.0002039068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003346587,"about_ca_topic_score_gemma":0.0004871998,"domain_scores_codex":[0.9998578,0.0000233227,0.00001823423,0.00002837526,0.00004376118,0.00002851445],"domain_scores_gemma":[0.9999294,0.000006814449,0.00002284881,0.00001004617,0.00001027932,0.00002060757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559813,0.00003975614,0.0001650743,0.00005655635,0.000006462687,0.00004826696,0.000009977316,0.0001353531,0.9957153,0.0001039579,0.0000543345,0.003508943],"study_design_scores_gemma":[0.00001313966,0.0003095475,0.001037951,0.000006926473,0.00001736094,0.0002089691,0.0000160584,0.0007761508,0.9952218,0.00005533709,0.002331648,0.000005113811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875888,0.003661903,0.005746564,0.0002444848,0.000062348,0.00005977906,0.0003379025,0.0002101632,0.002087964],"genre_scores_gemma":[0.9907843,0.001454082,0.005218706,0.00005610474,0.00001077022,0.00002975736,0.0003927277,0.00004359818,0.002010044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352743,"threshold_uncertainty_score":0.004525423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249509953104872,"score_gpt":0.2889983433405309,"score_spread":0.2765032438094822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}