{"id":"W4200507033","doi":"10.3390/ijms23010037","title":"The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"mTORC1; P70-S6 Kinase 1; AMPK; Chemistry; Cell biology; PI3K/AKT/mTOR pathway; Computer science; Biology; Signal transduction; Phosphorylation; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474076,0.0004321282,0.0003082781,0.0002058005,0.0002315857,0.000324932,0.0001811441,0.0003006232,0.002889081],"category_scores_gemma":[0.00008787083,0.0002081908,0.0003888317,0.0001308541,0.000246518,0.0002540089,0.0002395779,0.0006653665,0.0008975834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946381,"about_ca_system_score_gemma":0.0002074064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001147212,"about_ca_topic_score_gemma":0.0002598094,"domain_scores_codex":[0.9998426,0.00002138744,0.00001778718,0.00004387736,0.00002585574,0.00004847009],"domain_scores_gemma":[0.9999012,0.00000674303,0.00004125205,0.000009139987,0.00001026565,0.00003147799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004543613,0.00003074199,0.0001273771,0.00006731763,0.000006797471,0.00003955101,0.000008428506,0.00006224801,0.9978663,0.0001104607,0.00009603737,0.001130296],"study_design_scores_gemma":[0.00005816538,0.0005201004,0.005227969,0.0000153711,0.00002313809,0.0002674398,0.00003131515,0.0005165238,0.9891002,0.0001344813,0.004099375,0.000006027377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869533,0.004458215,0.003488014,0.0004305784,0.0001708354,0.00005002512,0.0009071256,0.000290623,0.003251319],"genre_scores_gemma":[0.9932085,0.001288167,0.001836511,0.000122094,0.0000343792,0.00007026022,0.0007392588,0.00004474137,0.00265616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002889081,"threshold_uncertainty_score":0.009664893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438363055633231,"score_gpt":0.2993535906411239,"score_spread":0.2849699600847916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}