{"id":"W4200514620","doi":"10.1002/dmrr.3515","title":"Comparative efficacy and safety of antihyperglycemic drug classes for patients with type 2 diabetes following failure with metformin monotherapy: A systematic review and network meta‐analysis of randomized controlled trials","year":2021,"lang":"en","type":"review","venue":"Diabetes/Metabolism Research and Reviews","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Calgary; Public Health Agency of Canada; University of Ottawa","funders":"","keywords":"Metformin; Medicine; Adverse effect; Type 2 diabetes; Internal medicine; Pharmacology; Randomized controlled trial; Diabetes mellitus; Hypoglycemia; Sitagliptin; Meta-analysis; Insulin; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.02101699,0.001007913,0.08302217,0.0009530883,0.0001620275,0.0001011233,0.0002206976,0.0001776312,0.00004254934],"category_scores_gemma":[0.003726045,0.0004215469,0.004671133,0.002497057,0.0004586575,0.0001493817,0.0001399183,0.0003572788,0.000001059455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003110936,"about_ca_system_score_gemma":0.0001937856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004576476,"about_ca_topic_score_gemma":0.000006591882,"domain_scores_codex":[0.9858679,0.00746978,0.004222689,0.0008815541,0.0008323533,0.000725692],"domain_scores_gemma":[0.9789544,0.01568221,0.003253286,0.0008243589,0.0009930906,0.0002926456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00376866,0.000300465,0.00006144178,0.5156953,0.4743385,0.000001472025,0.00006196649,3.252024e-7,6.289958e-7,0.000104067,0.000267823,0.005399363],"study_design_scores_gemma":[0.06433159,0.000535691,0.000005685127,0.1854066,0.7291772,2.691387e-7,0.00002127172,0.0000111205,0.000002374717,0.000008065358,0.0201934,0.0003066589],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001412686,0.9457108,0.000008701149,0.0000443221,0.00003531912,0.0526256,0.0001169598,0.00001192621,0.00003365869],"genre_scores_gemma":[0.0002164007,0.9890658,0.001574231,0.00007104189,0.00004020727,0.007962607,0.0006970777,0.00006572503,0.0003068768],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3302887,"threshold_uncertainty_score":0.9998236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09614539618507106,"score_gpt":0.399473025514376,"score_spread":0.303327629329305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}