{"id":"W4200517799","doi":"10.1101/2021.12.09.472002","title":"Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Université du Québec à Trois-Rivières; Université du Québec; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université du Québec à Trois-Rivières","keywords":"Mitochondrial DNA; Mitochondrion; Mitochondrial fission; Cell biology; Endoplasmic reticulum; mitochondrial fusion; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498483,0.0002503571,0.0002384473,0.0002155631,0.0003045404,0.0007097932,0.0002621461,0.0004334862,0.001446306],"category_scores_gemma":[0.0001640787,0.0002030259,0.0001704547,0.0001526798,0.0002647871,0.0004288071,0.0004847826,0.0005379459,0.001249441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000305988,"about_ca_system_score_gemma":0.0001127781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001986545,"about_ca_topic_score_gemma":0.0001927015,"domain_scores_codex":[0.999881,0.00001810688,0.000007290528,0.00003509925,0.00003559039,0.00002282166],"domain_scores_gemma":[0.9998239,0.00002453166,0.00005897689,0.00002262339,0.00002704821,0.00004292886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135755,0.00001178565,0.0003999004,0.00002227056,0.000002740183,0.00008735081,0.00001977911,0.00008098368,0.9981126,0.0002452301,0.00007395346,0.000829841],"study_design_scores_gemma":[0.00001970002,0.00005204103,0.01220425,0.0000100899,0.000008413764,0.0002797558,0.00008511899,0.003015115,0.9818164,0.0003218073,0.002180419,0.000007007211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891458,0.001688158,0.006015444,0.0001490659,0.00003995016,0.00001354665,0.0002146984,0.0001733234,0.002559902],"genre_scores_gemma":[0.993844,0.0004077037,0.001935441,0.0000282018,0.000009302583,0.00001228216,0.0002645563,0.00003785583,0.003460704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446306,"threshold_uncertainty_score":0.004838407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199397862260637,"score_gpt":0.2227179753928751,"score_spread":0.2107239967702687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}