{"id":"W4200520313","doi":"10.1093/brain/awab431","title":"Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital; Université du Québec à Montréal; Canadian Sleep & Circadian Network; Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"NIHR Oxford Biomedical Research Centre; Canadian Institutes of Health Research; Otsuka Pharmaceutical Development and Commercialization; Idorsia Pharmaceuticals; Deutsche Parkinson Vereinigung; H. Lundbeck A/S; Jazz Pharmaceuticals; Parkinson's UK; Eisai; Servier; Parkinson's Foundation; Deutsche Forschungsgemeinschaft; Engineering and Physical Sciences Research Council; UK Research and Innovation; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Medical Research Council; Biogen","keywords":"Synucleinopathies; Atrophy; Parkinson's disease; REM sleep behavior disorder; Dementia with Lewy bodies; Pathology; Disease; Medicine; Internal medicine; Alpha-synuclein; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775998,0.0001343095,0.0003005649,0.0001155127,0.00003737683,0.00001325399,0.00005842898,0.00007291096,0.0001297969],"category_scores_gemma":[0.0009476022,0.0001299244,0.00009651844,0.0003064608,0.00004150903,0.00006196588,0.00003553945,0.00007932469,0.00007948105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006576798,"about_ca_system_score_gemma":0.0001571119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000983323,"about_ca_topic_score_gemma":0.00002918494,"domain_scores_codex":[0.9988585,0.00009724472,0.0002936988,0.0003091885,0.0002411858,0.0002001536],"domain_scores_gemma":[0.9991843,0.0002077432,0.0000790695,0.0003348447,0.00008378494,0.0001102945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004565735,0.003444928,0.389484,0.0006135862,0.0002771941,0.002542918,0.0007271298,0.00005495633,0.551253,0.03540418,0.001372756,0.01436877],"study_design_scores_gemma":[0.001927613,0.0001960572,0.8988255,0.000312885,0.0001019643,0.00005261934,0.0001699458,0.0005926627,0.09486398,0.0007699736,0.002074048,0.0001128054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959182,0.001007732,0.000256718,0.001602738,0.0001180588,0.0002668583,0.00004014529,0.00003605649,0.000753513],"genre_scores_gemma":[0.9978265,0.00008442197,0.001119182,0.0003437403,0.00004135547,0.00003745718,0.000099048,0.00002347605,0.0004248348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5093414,"threshold_uncertainty_score":0.5298163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681452697304275,"score_gpt":0.2696411146252453,"score_spread":0.2528265876522026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}