{"id":"W4200520313","doi":"10.1093/brain/awab431","title":"Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital; Université du Québec à Montréal; Canadian Sleep & Circadian Network; Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"NIHR Oxford Biomedical Research Centre; Canadian Institutes of Health Research; Otsuka Pharmaceutical Development and Commercialization; Idorsia Pharmaceuticals; Deutsche Parkinson Vereinigung; H. Lundbeck A/S; Jazz Pharmaceuticals; Parkinson's UK; Eisai; Servier; Parkinson's Foundation; Deutsche Forschungsgemeinschaft; Engineering and Physical Sciences Research Council; UK Research and Innovation; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Medical Research Council; Biogen","keywords":"Synucleinopathies; Atrophy; Parkinson's disease; REM sleep behavior disorder; Dementia with Lewy bodies; Pathology; Disease; Medicine; Internal medicine; Alpha-synuclein; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001344998,0.000672942,0.0005908058,0.001841831,0.0002926934,0.0008908543,0.0003759031,0.0006800182,0.0008289911],"category_scores_gemma":[0.004883563,0.0002873964,0.0002763589,0.0005450267,0.0004354751,0.0004379853,0.0004314571,0.0003024591,0.0005050445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602336,"about_ca_system_score_gemma":0.0001848041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006676698,"about_ca_topic_score_gemma":0.0006982393,"domain_scores_codex":[0.999087,0.000249191,0.0001418632,0.0002331669,0.0002260489,0.00006275039],"domain_scores_gemma":[0.9977824,0.0009445529,0.0005489477,0.0001599331,0.0004102099,0.0001539412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002832239,0.0001734628,0.7497504,0.0003503283,0.0002129368,0.002112647,0.0004187695,0.0008624883,0.2005071,0.0001512309,0.0004608875,0.04216744],"study_design_scores_gemma":[0.00004739948,0.0008240141,0.9104464,0.0001627817,0.0002602974,0.00921535,0.0003789447,0.006568405,0.07006602,0.000453984,0.001524207,0.00005214977],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911664,0.004751715,0.00237374,0.00005590244,0.0000364979,0.00003600714,0.0003710219,0.0001049683,0.001103654],"genre_scores_gemma":[0.9956566,0.000645254,0.003122915,0.00003950707,0.0000164432,0.00001606084,0.0002723343,0.00001040418,0.0002204661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001841831,"threshold_uncertainty_score":0.007113099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681452697304275,"score_gpt":0.2696411146252453,"score_spread":0.2528265876522026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}