{"id":"W4200520404","doi":"10.1111/bph.15769","title":"Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish","year":2021,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundamental Research Funds for the Central Universities; Qingdao National Laboratory for Marine Science and Technology; National Natural Science Foundation of China","keywords":"Transdifferentiation; Zebrafish; Alpha cell; Cell culture; Biology; Cell biology; Cellular differentiation; Alpha (finance); BETA (programming language); Stem cell; Molecular biology; Beta cell; Biochemistry; Endocrinology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796973,0.000439435,0.0001982029,0.0004542573,0.0002191796,0.0002527589,0.0002258742,0.0003720687,0.002258224],"category_scores_gemma":[0.0001403721,0.0002435589,0.0004438901,0.0001494772,0.0002796372,0.0002875233,0.0002786158,0.0008185613,0.0006034416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000446704,"about_ca_system_score_gemma":0.0003760739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002619214,"about_ca_topic_score_gemma":0.004975341,"domain_scores_codex":[0.9998808,0.000006535473,0.00001459579,0.00003028325,0.00004771225,0.00002013328],"domain_scores_gemma":[0.9998379,0.00001976863,0.00005246552,0.00001456304,0.00002767461,0.00004767091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003595474,0.000004694844,0.0002295555,0.00003077458,0.000002220856,0.00006774596,0.00002373245,0.00002548462,0.9987336,0.00006821893,0.00002936083,0.000748598],"study_design_scores_gemma":[0.00003494443,0.0004215182,0.009670221,0.00003496954,0.00003985147,0.0004307513,0.0001196588,0.0006666038,0.9826128,0.00008344043,0.00587254,0.00001269931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802127,0.002144214,0.006473943,0.000242854,0.00009420096,0.0001515918,0.001210147,0.0002014936,0.00926891],"genre_scores_gemma":[0.9606373,0.002760808,0.009429174,0.0002680634,0.00002005148,0.0001593221,0.0009648828,0.0001008398,0.0256596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002619214,"threshold_uncertainty_score":0.007554471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014474043744756,"score_gpt":0.277921745639946,"score_spread":0.2634477018951901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}