{"id":"W4200523372","doi":"10.1158/1535-7163.targ-21-p246","title":"Abstract P246: Discovery and characterization of selective, FGFR1 sparing, inhibitors of FGFR2/3 oncogenic mutations for the treatment of cancers","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Street Contxt (Canada)","funders":"","keywords":"Cancer research; Allosteric regulation; Mutation; Fibroblast growth factor receptor 1; Gene; Cancer; Biology; Drug discovery; Genetics; Bioinformatics; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005247124,0.0001202214,0.0001781578,0.00003554923,0.00004116068,0.00001099229,0.00008290442,0.0000799113,0.000005220514],"category_scores_gemma":[0.00001132174,0.00009808715,0.0001232295,0.0001414056,0.0001475781,0.000006703879,0.00002648567,0.00003938783,5.85038e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000616192,"about_ca_system_score_gemma":0.0004003406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001605014,"about_ca_topic_score_gemma":0.0001367534,"domain_scores_codex":[0.9992302,0.00003610652,0.0002366785,0.0002052874,0.0001443112,0.0001474354],"domain_scores_gemma":[0.9992785,0.00003572748,0.0001768699,0.0002352621,0.0002475031,0.00002613886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154266,0.0001000929,0.004805201,0.00009363271,0.0005290704,6.651017e-7,0.0002466682,0.0004060433,0.9868722,0.00004071983,0.000002819977,0.006748605],"study_design_scores_gemma":[0.0006216679,0.0004231727,0.0213396,0.00003092856,0.0001144801,0.0000013118,0.00007457249,0.0001309848,0.9748759,0.00002528623,0.002276715,0.00008532961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991781,0.004247057,0.003165321,0.00009868978,0.0000740767,0.0003568108,0.0002515121,0.000002205548,0.00002332127],"genre_scores_gemma":[0.9959972,0.003481471,0.0001327306,0.00003345537,0.00004175179,0.00008029567,0.0001298612,0.00002502447,0.00007820655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0165344,"threshold_uncertainty_score":0.3999878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203547535401564,"score_gpt":0.3028328847848733,"score_spread":0.2807974094308577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}