{"id":"W4200523372","doi":"10.1158/1535-7163.targ-21-p246","title":"Abstract P246: Discovery and characterization of selective, FGFR1 sparing, inhibitors of FGFR2/3 oncogenic mutations for the treatment of cancers","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Street Contxt (Canada)","funders":"","keywords":"Cancer research; Allosteric regulation; Mutation; Fibroblast growth factor receptor 1; Gene; Cancer; Biology; Drug discovery; Genetics; Bioinformatics; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438189,0.000644319,0.0003915206,0.0005054236,0.0002079505,0.0004509554,0.0005548047,0.0004547464,0.002755234],"category_scores_gemma":[0.0002767388,0.0001572658,0.0004060686,0.0003811356,0.0001933518,0.0001998063,0.0002408081,0.0006926351,0.0009395673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003673813,"about_ca_system_score_gemma":0.0005130945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006872126,"about_ca_topic_score_gemma":0.0009556322,"domain_scores_codex":[0.9998361,0.00001797397,0.00001168271,0.00003620606,0.00007173137,0.00002626048],"domain_scores_gemma":[0.999916,0.00000740561,0.00001780596,0.000008095893,0.00001855987,0.00003222764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004283174,0.0003057703,0.0005991469,0.0001591712,0.00004609512,0.0003942749,0.00002682632,0.001886329,0.9724013,0.0005169914,0.001696517,0.02153932],"study_design_scores_gemma":[0.0007256966,0.005702212,0.003062129,0.00003123717,0.0001096155,0.0020232,0.0000299918,0.004536836,0.9543985,0.0003602688,0.02898479,0.00003568769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529617,0.01028957,0.01782328,0.0009073399,0.0001772575,0.001071137,0.005093636,0.0004916174,0.01118449],"genre_scores_gemma":[0.9636506,0.00491398,0.01590849,0.0004009772,0.00005075098,0.0004038998,0.005058684,0.000116717,0.00949593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002755234,"threshold_uncertainty_score":0.009217143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203547535401564,"score_gpt":0.3028328847848733,"score_spread":0.2807974094308577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}