{"id":"W4200531622","doi":"10.1016/j.lana.2021.100157","title":"Challenges of globalization of cancer drug trials- recruitment in LMICs, approval in HICs","year":2021,"lang":"en","type":"article","venue":"The Lancet Regional Health - Americas","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Ontario Institute for Cancer Research; Conquer Cancer Foundation","keywords":"Cancer drugs; Drug approval; Clinical trial; Drug trial; Drug; Medicine; Pharmacology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0618837,0.0007379762,0.001348718,0.001138026,0.004586369,0.01271263,0.003187704,0.008234003,0.02692575],"category_scores_gemma":[0.06276643,0.0006582327,0.001050858,0.00174995,0.01061461,0.009138525,0.01146509,0.01364683,0.003699682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01587811,"about_ca_system_score_gemma":0.05204848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02578157,"about_ca_topic_score_gemma":0.02726903,"domain_scores_codex":[0.9730726,0.01648297,0.001060891,0.002130739,0.002666618,0.00458616],"domain_scores_gemma":[0.9206197,0.03409789,0.007323003,0.003162518,0.01080232,0.02399446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006393052,0.0003995218,0.01566659,0.001987519,0.0002146237,0.001103475,0.005792402,0.002640832,0.001492205,0.2960334,0.547939,0.1260912],"study_design_scores_gemma":[0.0007182801,0.0005663534,0.02090424,0.003077019,0.0001010362,0.0006813881,0.01390886,0.002128443,0.0007893219,0.1684193,0.7885008,0.0002049559],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.007434102,0.006815578,0.001818358,0.9679001,0.00202498,0.000121315,0.0002768093,0.00008083251,0.01352782],"genre_scores_gemma":[0.2764523,0.01334239,0.008751717,0.6720836,0.01086115,0.001217163,0.0004302232,0.0002706808,0.01659084],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0618837,"threshold_uncertainty_score":0.3272762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2403284086237401,"score_gpt":0.4398956712607394,"score_spread":0.1995672626369994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}