{"id":"W4200532652","doi":"10.2174/1567205019666211222120448","title":"Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expressionby Protein Kinase C-λ/ι and Nuclear Factor κ-B","year":2021,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Deutsche Forschungsgemeinschaft; National Institute on Aging; National Institutes of Health; American Heart Association; National Institute of Environmental Health Sciences; U.S. Department of Veterans Affairs","keywords":"Hyperinsulinemia; Protein kinase C; Endocrinology; Internal medicine; Knockout mouse; Proinflammatory cytokine; Chemistry; Insulin; Kinase; Biology; Medicine; Inflammation; Insulin resistance; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002733967,0.0007046393,0.0001980626,0.000296131,0.0002536456,0.0004690941,0.0004676765,0.0002943613,0.002551041],"category_scores_gemma":[0.0001915741,0.0002446103,0.0003165564,0.0001735345,0.0005761313,0.0002723137,0.0003179323,0.0007183248,0.0005895756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005167255,"about_ca_system_score_gemma":0.0004564171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750075,"about_ca_topic_score_gemma":0.0006888125,"domain_scores_codex":[0.9996837,0.00003380542,0.00003213302,0.00009930322,0.00006148859,0.00008953332],"domain_scores_gemma":[0.999713,0.00001922818,0.0001283291,0.00003601194,0.00001970553,0.00008369923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004251892,0.00006203113,0.0002622983,0.00006127747,0.000006904631,0.00002415395,0.00001322543,0.00004109481,0.997588,0.0002559118,0.00003227378,0.001227695],"study_design_scores_gemma":[0.0001487042,0.0003660988,0.004365475,0.00001922461,0.00003065756,0.0001632867,0.00004818059,0.0008910741,0.9901737,0.0001571425,0.003628627,0.000007806849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862007,0.002892765,0.00836952,0.0001999441,0.0001483756,0.000092415,0.0004691091,0.0001883226,0.00143892],"genre_scores_gemma":[0.9869478,0.001679316,0.00674408,0.00007108608,0.00003429365,0.0002015428,0.0004560936,0.00003739434,0.003828593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002551041,"threshold_uncertainty_score":0.008534133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.101144221480016,"score_gpt":0.3908907419978473,"score_spread":0.2897465205178312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}