{"id":"W4200532652","doi":"10.2174/1567205019666211222120448","title":"Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expressionby Protein Kinase C-λ/ι and Nuclear Factor κ-B","year":2021,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Deutsche Forschungsgemeinschaft; National Institute on Aging; National Institutes of Health; American Heart Association; National Institute of Environmental Health Sciences; U.S. Department of Veterans Affairs","keywords":"Hyperinsulinemia; Protein kinase C; Endocrinology; Internal medicine; Knockout mouse; Proinflammatory cytokine; Chemistry; Insulin; Kinase; Biology; Medicine; Inflammation; Insulin resistance; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000598093,0.0003495939,0.0006314877,0.0003776662,0.0003561804,0.0001193502,0.0002362052,0.0001550347,0.001246178],"category_scores_gemma":[0.0006538097,0.0002890764,0.0002139272,0.000651878,0.0005605322,0.000276293,0.0004359317,0.000987015,0.0003063046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008291229,"about_ca_system_score_gemma":0.0007721953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006174189,"about_ca_topic_score_gemma":0.000004931255,"domain_scores_codex":[0.9949067,0.0007447278,0.000505097,0.0008674231,0.001887428,0.00108866],"domain_scores_gemma":[0.996529,0.0002015944,0.0001256252,0.0008416022,0.001186595,0.001115614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007758354,0.01037637,0.03248436,0.002928002,0.0190596,0.00191126,0.002264092,0.000001071757,0.7824319,0.002770167,0.005862586,0.1321522],"study_design_scores_gemma":[0.02478627,0.003435968,0.02693397,0.007476613,0.001999224,0.0001231139,0.0009431608,0.001221129,0.8909227,0.0008660456,0.03998462,0.001307158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8782984,0.116012,0.00002586347,0.0007162894,0.00006962562,0.003800822,0.0003128833,0.00007920225,0.0006848924],"genre_scores_gemma":[0.9983426,0.0003674275,0.0003279596,0.00001718797,0.0001775277,0.0004416485,0.0001032757,0.00008708507,0.0001353317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1308451,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.101144221480016,"score_gpt":0.3908907419978473,"score_spread":0.2897465205178312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}