{"id":"W4200536979","doi":"10.1182/bloodadvances.2021006043","title":"The MDM2 antagonist idasanutlin in patients with polycythemia vera: results from a single-arm phase 2 study","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Hematocrit; Nausea; Internal medicine; Gastroenterology; Vomiting; Ruxolitinib; Adverse effect; Polycythemia vera; Phlebotomy; Clinical endpoint; Regimen; Anemia; Surgery; Myelofibrosis; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008073716,0.0005130605,0.001309725,0.0001683277,0.0001789645,0.0005521157,0.000299429,0.0004427124,0.00100791],"category_scores_gemma":[0.0005963618,0.000185327,0.0005139274,0.0001984103,0.0002482204,0.0003190685,0.0001529119,0.001071311,0.0002459701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004333559,"about_ca_system_score_gemma":0.0004334864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431907,"about_ca_topic_score_gemma":0.001075371,"domain_scores_codex":[0.9997455,0.0001247864,0.00002002446,0.00003943576,0.00003748044,0.00003273314],"domain_scores_gemma":[0.999686,0.0000774885,0.0000631258,0.00002789442,0.000028061,0.0001174147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2792723,0.03374472,0.02981822,0.001572081,0.002965873,0.001501332,0.0006345629,0.00399491,0.2046962,0.0003413253,0.006348065,0.4351103],"study_design_scores_gemma":[0.2959675,0.5526856,0.1152756,0.0001261108,0.001416459,0.002767477,0.0001246924,0.005242669,0.01520783,0.0002838,0.01082347,0.00007893777],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936705,0.003962662,0.0003869843,0.0002437351,0.00004332715,0.0004148777,0.0003215583,0.00004831211,0.0009079335],"genre_scores_gemma":[0.9951237,0.001805282,0.0008880353,0.0004881363,0.0000902382,0.0002677655,0.0007941318,0.0000104504,0.0005322722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309725,"threshold_uncertainty_score":0.004269838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202265076328786,"score_gpt":0.2751350446058072,"score_spread":0.2631123938425194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}