{"id":"W4200536979","doi":"10.1182/bloodadvances.2021006043","title":"The MDM2 antagonist idasanutlin in patients with polycythemia vera: results from a single-arm phase 2 study","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Hematocrit; Nausea; Internal medicine; Gastroenterology; Vomiting; Ruxolitinib; Adverse effect; Polycythemia vera; Phlebotomy; Clinical endpoint; Regimen; Anemia; Surgery; Myelofibrosis; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009636404,0.0002289206,0.0003690677,0.00003667408,0.0002005794,0.00006799517,0.00008183032,0.00003600547,0.00002815368],"category_scores_gemma":[0.0001942138,0.0001323307,0.00004867613,0.0002499555,0.00007237559,0.0001113491,0.00004347593,0.0001610342,0.0000113539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006142629,"about_ca_system_score_gemma":0.0001163318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008256426,"about_ca_topic_score_gemma":0.001064004,"domain_scores_codex":[0.9983447,0.00009235315,0.0003850957,0.0005006314,0.000399217,0.0002779809],"domain_scores_gemma":[0.9988124,0.0003887537,0.0001360149,0.00042048,0.0001367274,0.0001056201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005317831,0.04109919,0.9252496,0.0000106861,0.0004089563,0.0007705717,0.001194366,0.0000067923,0.0002511779,0.00002455672,0.00009297741,0.02557327],"study_design_scores_gemma":[0.1439122,0.0180213,0.7306985,0.0005149235,0.0007452574,0.00001752228,0.003560129,0.00001765938,0.08194978,0.0001436105,0.01993837,0.0004807059],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944512,0.002534284,0.000002755257,0.0008575064,0.0001356944,0.0008048966,0.0001812434,0.00003024793,0.001002204],"genre_scores_gemma":[0.9982797,0.0002537765,0.0006186708,0.0001716524,0.0001176264,0.0001171301,0.0002362336,0.0000215871,0.0001836483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1945511,"threshold_uncertainty_score":0.539629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202265076328786,"score_gpt":0.2751350446058072,"score_spread":0.2631123938425194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}