{"id":"W4200539142","doi":"10.1371/journal.ppat.1010124","title":"Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets","year":2021,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Genetics and Genomics of Geneva; European Research Council; Radboud Universitair Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Radboud Universiteit; Netherlands Organization for International Cooperation in Higher Education; European Commission","keywords":"Biology; Apicomplexa; Apicoplast; Antiparasitic agent; Antiparasitic; Drug discovery; Plasmodium (life cycle); Plasmodium falciparum; Computational biology; Biochemistry; Malaria; Parasite hosting; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265597,0.0006164235,0.000979381,0.001349339,0.0002570028,0.0009944229,0.0004338122,0.0008355257,0.002162678],"category_scores_gemma":[0.0003372839,0.0002410436,0.0003797739,0.001325121,0.0002460329,0.001261436,0.0004909615,0.001033279,0.0008865636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006150866,"about_ca_system_score_gemma":0.0009075843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008969094,"about_ca_topic_score_gemma":0.001500776,"domain_scores_codex":[0.9998884,0.00001357827,0.00002058633,0.0000209191,0.00003758707,0.0000188468],"domain_scores_gemma":[0.9998637,0.00003526298,0.00003756503,0.000003501792,0.00003909686,0.0000208297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004829384,0.0001150709,0.001298837,0.03293624,0.0002472284,0.001471428,0.0003409346,0.001840399,0.06725995,0.009135512,0.03186907,0.8530023],"study_design_scores_gemma":[0.00002308215,0.0002709058,0.002702774,0.0009103335,0.0002291401,0.001757078,0.0001312079,0.0004660943,0.005866599,0.002459586,0.9851416,0.00004158197],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001458473,0.9962173,0.0003867925,0.0003731476,0.0001699615,0.000008339338,0.00006247546,0.00002051666,0.001303046],"genre_scores_gemma":[0.005272663,0.992597,0.0005319318,0.0002405861,0.0002952661,0.00001198145,0.0001745248,0.000003612914,0.0008724733],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002162678,"threshold_uncertainty_score":0.007234812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0811785805366201,"score_gpt":0.30929041511649,"score_spread":0.2281118345798699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}