{"id":"W4200539142","doi":"10.1371/journal.ppat.1010124","title":"Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets","year":2021,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Genetics and Genomics of Geneva; European Research Council; Radboud Universitair Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Radboud Universiteit; Netherlands Organization for International Cooperation in Higher Education; European Commission","keywords":"Biology; Apicomplexa; Apicoplast; Antiparasitic agent; Antiparasitic; Drug discovery; Plasmodium (life cycle); Plasmodium falciparum; Computational biology; Biochemistry; Malaria; Parasite hosting; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002190034,0.0005679041,0.002241455,0.0001923345,0.000118545,0.0001223867,0.000275105,0.000169414,0.0001547517],"category_scores_gemma":[0.001369464,0.0003673934,0.0003419559,0.0003295976,0.0003468692,0.00007598248,0.0002796625,0.0003544145,0.00007379799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001352407,"about_ca_system_score_gemma":0.0000963723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006641882,"about_ca_topic_score_gemma":0.000001818718,"domain_scores_codex":[0.996336,0.001234752,0.000533107,0.00117332,0.0002079873,0.0005148781],"domain_scores_gemma":[0.9978608,0.00117616,0.0002277539,0.0004265184,0.00002163588,0.0002870619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001295661,0.0009176257,0.00003205137,0.01196714,0.00009446642,0.002351011,0.0003564033,2.071397e-7,0.008361124,0.005703889,0.00004164575,0.9700449],"study_design_scores_gemma":[0.002051477,0.0001063245,0.0001372364,0.006939148,0.001259405,0.0004309168,0.00003813943,0.0001398824,0.003000053,0.002548325,0.9818814,0.001467624],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02626175,0.9709212,6.104268e-7,0.00008106508,0.00008185321,0.001392206,0.0006253251,0.00006438979,0.0005716452],"genre_scores_gemma":[0.007100792,0.9918206,0.00003128106,0.0004582216,0.00006772968,0.0002163926,0.00001463437,0.00006460919,0.000225754],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9818398,"threshold_uncertainty_score":0.9998778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0811785805366201,"score_gpt":0.30929041511649,"score_spread":0.2281118345798699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}