{"id":"W4200540288","doi":"10.3390/biom12010015","title":"Connexin 43 Gene Ablation Does Not Alter Human Pluripotent Stem Cell Germ Lineage Specification","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Endoderm; Induced pluripotent stem cell; Germ layer; Biology; Ectoderm; Cell biology; Embryoid body; Mesoderm; Embryonic stem cell; Connexin; Genetics; Gap junction; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140458,0.0002047172,0.000172356,0.00005217121,0.0001295603,0.00005036674,0.0001635074,0.0002202793,0.0001205127],"category_scores_gemma":[0.00001323831,0.0001727223,0.0001365191,0.00008569583,0.0001131018,0.000004321762,0.0001266048,0.00007613662,0.00004861732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002150257,"about_ca_system_score_gemma":0.00006283887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002655351,"about_ca_topic_score_gemma":0.0000993119,"domain_scores_codex":[0.9985834,0.0001253861,0.0003248786,0.0005810236,0.0001156145,0.0002696861],"domain_scores_gemma":[0.9990637,0.00001247044,0.0001386755,0.0005320407,0.000166877,0.00008626928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004204364,0.0001018286,0.0002417018,0.00001794488,0.00003391417,0.00002658443,0.00004438315,0.000006165623,0.9959947,0.0007844056,0.000408284,0.002298065],"study_design_scores_gemma":[0.0004764039,0.0001284205,0.00243511,0.000006569513,0.00002065387,0.00001863221,0.0001134876,0.00004097269,0.9477951,0.00003155415,0.04868015,0.0002529634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916667,0.001189628,0.004603178,0.0005683818,0.0002758234,0.0001679504,0.00009029836,0.00002894283,0.001409104],"genre_scores_gemma":[0.9929044,0.0002920474,0.0007772738,0.0005807968,0.0005683231,0.00002079186,0.000963851,0.00003030933,0.003862176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04827186,"threshold_uncertainty_score":0.7043412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666351544674016,"score_gpt":0.2505156243750047,"score_spread":0.2338521089282645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}