{"id":"W4200540415","doi":"10.1126/sciadv.abi5568","title":"Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; McMaster University","funders":"National Human Genome Research Institute","keywords":"Medulloblastoma; Profiling (computer programming); Gene expression profiling; Medicine; Oncology; Bioinformatics; Computational biology; Cancer research; Gene; Biology; Gene expression; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003053737,0.00008688603,0.0002572303,0.00016033,0.00008012403,0.00001201309,0.0001479808,0.00001918393,0.00002417934],"category_scores_gemma":[0.0001500561,0.00007020854,0.00004755349,0.001131493,0.0005986894,0.000407073,0.0000357696,0.00005488081,8.445183e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004537824,"about_ca_system_score_gemma":0.0002669198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003548217,"about_ca_topic_score_gemma":0.0002874629,"domain_scores_codex":[0.9987251,0.00001340195,0.0002834204,0.0003111726,0.00046179,0.000205162],"domain_scores_gemma":[0.999227,0.00004195077,0.000165713,0.0002369202,0.0002772272,0.0000511815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002642183,0.0003280826,0.2428406,0.0000628992,0.000006324876,0.00001990798,0.000309815,0.00003887306,0.7545907,0.0009300696,0.000006694429,0.0008396044],"study_design_scores_gemma":[0.0008099647,0.00009786204,0.06980772,0.0003546571,0.000006020657,0.000002850116,0.0008442421,0.000009189303,0.927035,0.0006936407,0.0002800082,0.00005886181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913149,0.007366512,0.00003171717,0.0001551548,0.0001325399,0.0001769445,0.00001032368,0.000007924283,0.0008039767],"genre_scores_gemma":[0.9876742,0.0002793454,0.01190164,0.00001552124,0.000008990188,0.00001629014,0.000004453373,0.000003820012,0.0000957755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1730329,"threshold_uncertainty_score":0.2863021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329128419477018,"score_gpt":0.321596776636858,"score_spread":0.2983054924420878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}