{"id":"W4200541412","doi":"10.3390/antibiotics10121529","title":"Exploration of the Structure–Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Antimicrobial peptides; Rational design; Antimicrobial; Peptide; In vitro; Frog Skin; Template; Computational biology; Function (biology); Biology; Combinatorial chemistry; Escherichia coli; Chemistry; Biochemistry; Microbiology; Nanotechnology; Cell biology; Materials science; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181107,0.00009961954,0.0002411437,0.0000458448,0.0001185761,0.000006513581,0.00004328221,0.0001138493,0.00001443814],"category_scores_gemma":[0.0002605519,0.0000813859,0.00004782116,0.0001824893,0.0003711776,0.0003458113,0.00005908877,0.0001405247,4.459022e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889925,"about_ca_system_score_gemma":0.0001013303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216928,"about_ca_topic_score_gemma":0.0002106743,"domain_scores_codex":[0.9991407,0.0002068921,0.0003633385,0.0001537253,0.0000466547,0.00008872481],"domain_scores_gemma":[0.9988343,0.0003482776,0.0003503324,0.0001408095,0.0003221759,0.000004066867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001823472,0.0001820447,0.002170168,0.00004786751,0.0001756712,9.416844e-8,0.00249081,0.0008734007,0.9918215,0.001925953,0.00006932246,0.00006079482],"study_design_scores_gemma":[0.0004905635,0.00005267778,0.01924315,0.00009695216,0.0000644998,0.00000292353,0.003257592,0.00008537427,0.9757605,0.0008517429,0.00002435282,0.00006970632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463825,0.0003977435,0.05252819,0.000171658,0.0001817366,0.0002136091,0.0001115024,0.00000365538,0.000009402544],"genre_scores_gemma":[0.9930327,0.0003284728,0.006349246,0.00003390784,0.000009283684,4.940807e-7,0.0001295669,0.000005793978,0.0001105597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04665017,"threshold_uncertainty_score":0.3318821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08925552738320351,"score_gpt":0.2733979998892703,"score_spread":0.1841424725060667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}