{"id":"W4200541412","doi":"10.3390/antibiotics10121529","title":"Exploration of the Structure–Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Antimicrobial peptides; Rational design; Antimicrobial; Peptide; In vitro; Frog Skin; Template; Computational biology; Function (biology); Biology; Combinatorial chemistry; Escherichia coli; Chemistry; Biochemistry; Microbiology; Nanotechnology; Cell biology; Materials science; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013208,0.0003116213,0.0001891459,0.0001283213,0.00009271835,0.0002391465,0.0001650694,0.0002218409,0.0006799132],"category_scores_gemma":[0.0001689023,0.00008804302,0.0002229907,0.0001429481,0.0001469247,0.0002379218,0.0001249082,0.0003465076,0.0001931605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376061,"about_ca_system_score_gemma":0.0001547905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558825,"about_ca_topic_score_gemma":0.0002442081,"domain_scores_codex":[0.9999409,0.00001315595,0.000005460004,0.00001267645,0.00001637878,0.00001143903],"domain_scores_gemma":[0.999947,0.0000135887,0.00001944881,0.000002927881,0.000007278254,0.000009828282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006524728,0.00003969335,0.0004351788,0.00009981496,0.000006862076,0.0001344413,0.00001552026,0.00176533,0.9931838,0.0002825833,0.00001883704,0.003952688],"study_design_scores_gemma":[0.00001755129,0.0007342866,0.001975053,0.000008969094,0.00002266176,0.0003492401,0.00002735776,0.005679167,0.98781,0.0001207214,0.003244314,0.00001074736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886052,0.003381814,0.006436329,0.0000860567,0.0000119574,0.0000394097,0.000150656,0.00002355504,0.001265031],"genre_scores_gemma":[0.9891355,0.002811175,0.006900186,0.00003022754,0.000006136432,0.00001869757,0.0002097281,0.000006293119,0.0008821512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006799132,"threshold_uncertainty_score":0.002274513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08925552738320351,"score_gpt":0.2733979998892703,"score_spread":0.1841424725060667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}