{"id":"W4200549730","doi":"10.1093/ofid/ofab466.1242","title":"1048. Double-Blind, Randomized, Placebo-Controlled Phase 2b Multicenter Trial of V160, a Replication-Defective Human Cytomegalovirus (CMV) Vaccine","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Placebo; Adverse effect; Vaccination; Immunology; Regimen; Saliva; Antibody; Internal medicine; Immunity; Human cytomegalovirus; Urine; Incidence (geometry); Cytomegalovirus; Randomized controlled trial; Immune system; Virology; Human immunodeficiency virus (HIV); Virus; Viral disease; Herpesviridae; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002216212,0.002212811,0.003496656,0.0007108204,0.0007747857,0.0009890693,0.001139235,0.003198958,0.01557097],"category_scores_gemma":[0.002401506,0.001080988,0.001014908,0.0005553254,0.00129526,0.001151957,0.000378117,0.002703969,0.002443535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006044573,"about_ca_system_score_gemma":0.001442419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006984244,"about_ca_topic_score_gemma":0.001388279,"domain_scores_codex":[0.99885,0.0006206718,0.00007995563,0.0002167365,0.00006709453,0.0001656108],"domain_scores_gemma":[0.9990985,0.0002120961,0.0001858049,0.00008157218,0.0001044876,0.0003175212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9791501,0.007931909,0.0002401265,0.0004457996,0.0002942613,0.00001649633,0.0000213126,0.0001336056,0.002328059,0.00007537404,0.0009269548,0.008436084],"study_design_scores_gemma":[0.960392,0.03840305,0.0003990273,0.00001728427,0.00007139824,0.000006978045,0.000005045971,0.0001283845,0.0001496405,0.00005894725,0.0003628435,0.000005350518],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359776,0.006583239,0.002200814,0.001662031,0.002537515,0.03936705,0.005137125,0.000645418,0.005889311],"genre_scores_gemma":[0.9239379,0.002718707,0.005541029,0.003163081,0.001059416,0.04953014,0.002774527,0.00008239275,0.01119264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01557097,"threshold_uncertainty_score":0.05209005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03925655610820375,"score_gpt":0.3930915837571907,"score_spread":0.3538350276489869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}