{"id":"W4200549730","doi":"10.1093/ofid/ofab466.1242","title":"1048. Double-Blind, Randomized, Placebo-Controlled Phase 2b Multicenter Trial of V160, a Replication-Defective Human Cytomegalovirus (CMV) Vaccine","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Placebo; Adverse effect; Vaccination; Immunology; Regimen; Saliva; Antibody; Internal medicine; Immunity; Human cytomegalovirus; Urine; Incidence (geometry); Cytomegalovirus; Randomized controlled trial; Immune system; Virology; Human immunodeficiency virus (HIV); Virus; Viral disease; Herpesviridae; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001338032,0.0005171131,0.002732413,0.0005007378,0.0005229657,0.0003495339,0.0004562318,0.0002239624,0.003459286],"category_scores_gemma":[0.002023359,0.0004236683,0.001267393,0.0008225481,0.0002740598,0.0004997519,0.0005822717,0.00047894,0.0002131503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195536,"about_ca_system_score_gemma":0.0008364726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779547,"about_ca_topic_score_gemma":0.0007856404,"domain_scores_codex":[0.9952485,0.0006114967,0.001466278,0.001132067,0.0007894262,0.0007522081],"domain_scores_gemma":[0.9949585,0.0009579258,0.0006574611,0.001720332,0.001079084,0.0006267109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9719135,0.009552087,0.00442693,0.0001485768,0.002170191,0.0001307015,0.0001729725,0.00001170411,0.003242542,0.00228578,0.00311499,0.002830076],"study_design_scores_gemma":[0.9823687,0.001781489,0.0002992907,0.0001685079,0.001649758,0.00005113264,0.0002181728,0.0002657893,0.006884219,0.0007634686,0.005139638,0.0004098471],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9276153,0.001096838,0.0001671991,0.001074,0.0003498014,0.01889376,0.000239407,0.0001639734,0.05039967],"genre_scores_gemma":[0.9894276,0.000301308,0.00004742533,0.0006243259,0.0003387013,0.004485265,0.0004793759,0.0001023713,0.0041936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06181227,"threshold_uncertainty_score":0.9998215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03925655610820375,"score_gpt":0.3930915837571907,"score_spread":0.3538350276489869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}