{"id":"W4200553008","doi":"10.1128/mbio.03273-21","title":"A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Deutsche Forschungsgemeinschaft; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; DNA damage; Histone; DNA repair; Cell biology; Chaperone (clinical); DNA replication; Cryptococcus neoformans; Gene; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066209,0.0001384979,0.0002988174,0.0001636122,0.000302657,0.00003830407,0.00005077213,0.0000628384,0.0002501539],"category_scores_gemma":[0.000527282,0.0001008856,0.00006341954,0.0005065325,0.000123817,0.0000353691,0.0001766193,0.0003614882,0.00007481915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426689,"about_ca_system_score_gemma":0.0001091433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005903857,"about_ca_topic_score_gemma":0.002471109,"domain_scores_codex":[0.998764,0.0003086593,0.0002256248,0.0003114941,0.0001444,0.000245795],"domain_scores_gemma":[0.9993035,0.00009392547,0.00002458916,0.0003376291,0.00009293795,0.0001473747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003198168,0.0002971006,0.001449689,0.00003187504,0.00006091085,0.0004468791,0.006139175,0.000001683876,0.9797923,0.00772604,0.0005028363,0.0003533632],"study_design_scores_gemma":[0.01028905,0.003524532,0.7283986,0.0004046586,0.0001481158,0.000605102,0.0214178,0.00001863666,0.007376899,0.0032285,0.2239746,0.0006135244],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714993,0.0003102842,0.0002508067,0.02462485,0.00005341437,0.001013658,0.00003019579,0.00003596881,0.002181516],"genre_scores_gemma":[0.9880196,0.00000521552,0.0008252951,0.001531595,0.00008355825,0.000447513,0.00001074526,0.00001575787,0.009060721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9724154,"threshold_uncertainty_score":0.4113995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498361715275159,"score_gpt":0.2928733440144571,"score_spread":0.2778897268617055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}