{"id":"W4200555383","doi":"10.1111/acel.13531","title":"Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manitoba Health; St. Boniface Hospital; CancerCare Manitoba; University of Manitoba","funders":"National Institute on Aging; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Disease; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026831,0.0002117951,0.0002036828,0.0002483724,0.0001551191,0.0004118204,0.0001154446,0.0002804336,0.0006346412],"category_scores_gemma":[0.0002292946,0.00008641226,0.0002496756,0.00009848782,0.0003072066,0.0002219162,0.0001998011,0.0002237587,0.0002013752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291888,"about_ca_system_score_gemma":0.0002510824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003489126,"about_ca_topic_score_gemma":0.0003776232,"domain_scores_codex":[0.9999011,0.0000299588,0.00001181641,0.0000208941,0.00001595147,0.00002032367],"domain_scores_gemma":[0.9998888,0.00001888221,0.000039954,0.000009640989,0.00001827456,0.00002456723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007331792,0.0000595786,0.002402341,0.0001595553,0.0000230418,0.000489301,0.0000673539,0.0001025107,0.9908839,0.0003397269,0.0001236819,0.004615829],"study_design_scores_gemma":[0.000132912,0.001157717,0.06035433,0.00005431889,0.00008071723,0.003171345,0.0002601036,0.001696708,0.9254861,0.0007599503,0.006819711,0.00002602573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986559,0.009676654,0.001537001,0.000343456,0.0000306788,0.00002669995,0.0001574123,0.00007819177,0.001590844],"genre_scores_gemma":[0.9967444,0.00180665,0.0006185467,0.000048722,0.000009722363,0.00001405576,0.00008163424,0.000004791088,0.0006714428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006346412,"threshold_uncertainty_score":0.003113985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944103009291885,"score_gpt":0.2761277231182044,"score_spread":0.2566866930252856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}