{"id":"W4200556990","doi":"10.1016/j.atherosclerosis.2021.11.030","title":"Polygenic risk scores for cardiovascular disease prediction in the clinical practice: Are we there?","year":2021,"lang":"en","type":"letter","venue":"Atherosclerosis","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"Medicines Company; Ionis Pharmaceuticals; AstraZeneca; Regeneron Pharmaceuticals; Novartis; Fondation Leducq; Amgen; Pfizer; Sanofi; Merck","keywords":"Genome-wide association study; Scopus; Polygenic risk score; Schizophrenia (object-oriented programming); Single-nucleotide polymorphism; Disease; Genetic association; SNP; Bipolar disorder; Genetics; Medicine; Bioinformatics; Internal medicine; Biology; MEDLINE; Psychiatry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01612796,0.0009267732,0.003622882,0.001183084,0.00244055,0.004513735,0.002171568,0.0295212,0.005027032],"category_scores_gemma":[0.08506991,0.0009538853,0.001095884,0.001348037,0.003449376,0.005068362,0.001638549,0.02726697,0.00406509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002743285,"about_ca_system_score_gemma":0.004412421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005952553,"about_ca_topic_score_gemma":0.01113856,"domain_scores_codex":[0.9892182,0.005885944,0.001443733,0.0007019709,0.002317762,0.0004323117],"domain_scores_gemma":[0.9169124,0.05954473,0.002598847,0.001990645,0.01266334,0.006290006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003892943,0.000139441,0.01204879,0.0001683289,0.0001224892,0.001453709,0.0001979916,0.0002444177,0.0001928042,0.00573253,0.9110485,0.06826172],"study_design_scores_gemma":[0.001954548,0.0005853515,0.03056526,0.003053101,0.0004859649,0.006526974,0.001949111,0.009575132,0.0005439399,0.1423498,0.8018802,0.0005306737],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003754608,0.002338737,0.0001922133,0.9895765,0.00689389,0.000005605181,0.00004480227,0.00001341524,0.0005593589],"genre_scores_gemma":[0.01290213,0.006931383,0.002121989,0.8260921,0.1496111,0.00009066401,0.0001000606,0.00003769291,0.002112782],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0295212,"threshold_uncertainty_score":0.08529383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05898873436021654,"score_gpt":0.317128072295096,"score_spread":0.2581393379348794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}