{"id":"W4200557046","doi":"10.1158/1078-0432.ccr-21-1291","title":"Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Discontinuation; Regimen; Medicine; Internal medicine; Gastroenterology; Toxicity; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001710494,0.0008878816,0.00126331,0.0004060376,0.000235495,0.0008791416,0.0007852232,0.0006270001,0.001269979],"category_scores_gemma":[0.0004043996,0.0003639905,0.0008358489,0.0003667455,0.0006330959,0.0007304699,0.0003263508,0.002224462,0.0003799803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007504728,"about_ca_system_score_gemma":0.001079224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005053407,"about_ca_topic_score_gemma":0.002037011,"domain_scores_codex":[0.9996004,0.0001632715,0.00003413478,0.00005787609,0.00006173329,0.00008275272],"domain_scores_gemma":[0.9996214,0.00006606002,0.00008816462,0.00003693569,0.00002831374,0.0001590554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2149692,0.0948464,0.01076998,0.001805618,0.001956635,0.0005148244,0.0006018668,0.007332207,0.4781011,0.0006589965,0.003985477,0.1844578],"study_design_scores_gemma":[0.1837061,0.6935436,0.02291353,0.00009671027,0.001439635,0.0009297259,0.0001951674,0.003597222,0.08507265,0.0002381393,0.00820676,0.00006093981],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941468,0.002478115,0.0008257291,0.0002071598,0.00004697364,0.0008122501,0.000377259,0.00006465292,0.001041011],"genre_scores_gemma":[0.994077,0.001543783,0.002026986,0.0002189585,0.00004496382,0.0005784951,0.0008132859,0.00001701942,0.0006795893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710494,"threshold_uncertainty_score":0.009046018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.164422879325362,"score_gpt":0.4935262293066927,"score_spread":0.3291033499813307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}