{"id":"W4200557046","doi":"10.1158/1078-0432.ccr-21-1291","title":"Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Discontinuation; Regimen; Medicine; Internal medicine; Gastroenterology; Toxicity; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005895206,0.0002348303,0.0009709372,0.00007860696,0.0001304797,0.00001618069,0.0001312889,0.00009840094,0.0001121058],"category_scores_gemma":[0.0005845305,0.0001176048,0.00008201719,0.0004078703,0.00105741,0.00005893862,0.00005613084,0.000294398,1.425004e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007841765,"about_ca_system_score_gemma":0.0005221503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581437,"about_ca_topic_score_gemma":0.0007136712,"domain_scores_codex":[0.9968863,0.0004273326,0.0009618592,0.0006423714,0.0007134746,0.000368703],"domain_scores_gemma":[0.9938101,0.003702614,0.000416724,0.0005081683,0.001377034,0.0001853758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2238299,0.01921393,0.5750394,0.0004038005,0.00340031,0.00004725039,0.006521735,0.00001634468,0.001660492,0.000004080501,0.00007612476,0.1697867],"study_design_scores_gemma":[0.2132986,0.06595057,0.570528,0.001357099,0.001424744,0.000003475367,0.006723825,0.0009149091,0.1383529,0.00007864035,0.001005273,0.0003619476],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918659,0.00358118,0.0001861843,0.0003051142,0.00005186416,0.00302311,0.0009660341,0.00001295755,0.000007686283],"genre_scores_gemma":[0.9980752,0.0004151546,0.0006571673,0.00001620436,0.0001140527,0.000278182,0.0002584701,0.00004372914,0.0001418184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1694247,"threshold_uncertainty_score":0.4795784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.164422879325362,"score_gpt":0.4935262293066927,"score_spread":0.3291033499813307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}