{"id":"W4200559094","doi":"10.1136/annrheumdis-2021-221295","title":"Flares after hydroxychloroquine reduction or discontinuation: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Toronto Western Hospital; University of Toronto; Université Laval; Queen Elizabeth II Health Sciences Centre; McGill University; University of Calgary; McGill University Health Centre","funders":"Niilo Helanderin Säätiö; National Center for Chronic Disease Prevention and Health Promotion; Fonds de Recherche du Québec - Santé; Centers for Disease Control and Prevention; McGill University Health Centre; National Institutes of Health; National Center for Research Resources; Versus Arthritis; Novo Nordisk Fonden; National Center for Advancing Translational Sciences; Institut de recherche, Centre universitaire de santé McGill; National Research Foundation of Korea; Eusko Jaurlaritza; Arthritis Research UK; Novo Nordisk; National Institute for Health and Care Research; Canadian Institutes of Health Research; Gigtforeningen; McGill University; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Wellcome; Lupus Research Alliance; Manchester Clinical Research Facility; Sandwell and West Birmingham Hospitals NHS Trust; Wellcome Trust; University of Calgary; Arthritis Society; Johns Hopkins University; National Research Foundation","keywords":"Medicine; Hydroxychloroquine; Systemic lupus; Discontinuation; Systemic lupus erythematosus; Cohort; Internal medicine; Dermatology; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002519147,0.0004009222,0.0006390105,0.0007517586,0.0003963452,0.0008300415,0.0006940659,0.0004857011,0.002093004],"category_scores_gemma":[0.004681569,0.0003690144,0.001251243,0.001351548,0.0002237282,0.000442706,0.0007099278,0.0007145086,0.000232405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000592912,"about_ca_system_score_gemma":0.0006184843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03140574,"about_ca_topic_score_gemma":0.03113316,"domain_scores_codex":[0.9983913,0.0003597454,0.0001542024,0.000546275,0.0002752107,0.000273187],"domain_scores_gemma":[0.995161,0.000821592,0.002325063,0.000684753,0.0004931362,0.000514443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005142242,0.00001558645,0.997918,0.00001637456,0.0002458876,0.00003254713,0.00005253113,0.00005818804,0.00009762067,0.000009274755,0.0002596788,0.0007800509],"study_design_scores_gemma":[0.0000358114,0.00008729089,0.9993369,0.000008058768,0.0001252005,0.00008393074,0.00005931024,0.0000927904,0.00002702078,0.000005581443,0.000134525,0.000003608107],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939141,0.0005024597,0.00009347229,0.00005332676,0.000008293629,0.00002182082,0.005025038,0.000007400591,0.000374118],"genre_scores_gemma":[0.995359,0.0001330831,0.00007219882,0.00005836226,0.00001538527,0.00002093441,0.004160243,0.000007779097,0.0001730071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03140574,"threshold_uncertainty_score":0.06244588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04544910492875849,"score_gpt":0.3477999124252471,"score_spread":0.3023508074964886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}