{"id":"W4200559094","doi":"10.1136/annrheumdis-2021-221295","title":"Flares after hydroxychloroquine reduction or discontinuation: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Toronto Western Hospital; University of Toronto; Université Laval; Queen Elizabeth II Health Sciences Centre; McGill University; University of Calgary; McGill University Health Centre","funders":"Niilo Helanderin Säätiö; National Center for Chronic Disease Prevention and Health Promotion; Fonds de Recherche du Québec - Santé; Centers for Disease Control and Prevention; McGill University Health Centre; National Institutes of Health; National Center for Research Resources; Versus Arthritis; Novo Nordisk Fonden; National Center for Advancing Translational Sciences; Institut de recherche, Centre universitaire de santé McGill; National Research Foundation of Korea; Eusko Jaurlaritza; Arthritis Research UK; Novo Nordisk; National Institute for Health and Care Research; Canadian Institutes of Health Research; Gigtforeningen; McGill University; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Wellcome; Lupus Research Alliance; Manchester Clinical Research Facility; Sandwell and West Birmingham Hospitals NHS Trust; Wellcome Trust; University of Calgary; Arthritis Society; Johns Hopkins University; National Research Foundation","keywords":"Medicine; Hydroxychloroquine; Systemic lupus; Discontinuation; Systemic lupus erythematosus; Cohort; Internal medicine; Dermatology; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000897011,0.0001934566,0.000469656,0.0000604664,0.0001503083,0.0001062273,0.0003794786,0.00008506833,0.0002782321],"category_scores_gemma":[0.006864154,0.0001036669,0.0002402389,0.0005176056,0.0001868612,0.000218959,0.0002373279,0.0001652479,0.00003827627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008818431,"about_ca_system_score_gemma":0.0005631105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001205462,"about_ca_topic_score_gemma":0.00006240045,"domain_scores_codex":[0.9966026,0.0004911396,0.001135798,0.0003867699,0.001148358,0.0002353277],"domain_scores_gemma":[0.9961666,0.000961016,0.000625759,0.001050515,0.001079075,0.0001170667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00765222,0.001184525,0.8829979,0.001388583,0.002669284,0.00008515608,0.01182721,0.0003768024,0.001440115,0.0001905136,0.06904057,0.02114717],"study_design_scores_gemma":[0.0202216,0.0008887351,0.72983,0.08732741,0.002796362,0.0116974,0.1054501,0.02166941,0.01011762,0.003319109,0.005187373,0.001494887],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832547,0.003207389,0.0000425031,0.01000668,0.001600464,0.0009412891,0.0005746934,0.00004432901,0.0003279725],"genre_scores_gemma":[0.993219,0.001639685,0.0001083618,0.0002431816,0.0004529907,0.0001603125,0.0003447587,0.00002832765,0.003803413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1531678,"threshold_uncertainty_score":0.8217529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04544910492875849,"score_gpt":0.3477999124252471,"score_spread":0.3023508074964886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}