{"id":"W4200563501","doi":"10.1158/1535-7163.targ-21-lba021","title":"Abstract LBA021: Immune resistance interrogation study (IRIS): Initial report of next generation sequencing (NGS) results in patients with primary versus acquired resistance to anti-PD1/L1 antibodies","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Antibody; Cancer; Biopsy; Liquid biopsy; Internal medicine; Oncology; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001149129,0.0001972424,0.0003785121,0.0003925653,0.0002762161,0.0007163409,0.0002110476,0.0004530097,0.002505188],"category_scores_gemma":[0.002505749,0.0001551802,0.0002498232,0.0003881183,0.0002291136,0.0003026149,0.0003554307,0.0004854232,0.000566147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004790661,"about_ca_system_score_gemma":0.000174678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007465606,"about_ca_topic_score_gemma":0.000772196,"domain_scores_codex":[0.9992124,0.0001995129,0.00008588843,0.0002616884,0.0001536826,0.00008681819],"domain_scores_gemma":[0.9987294,0.0003802028,0.0004266093,0.0001009375,0.0001763409,0.0001865738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006050476,0.0001463768,0.9750444,0.00005669901,0.00008041265,0.0007472163,0.000148479,0.0001682285,0.008701408,0.00007125919,0.001512643,0.007272421],"study_design_scores_gemma":[0.0002682612,0.001894848,0.98812,0.00002257996,0.00009869218,0.003436707,0.0001663463,0.0009409423,0.00295145,0.00007192927,0.002014333,0.00001400404],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946548,0.0002831708,0.0003171538,0.0001131134,0.000008662589,0.00007566536,0.002737736,0.00002189484,0.001787808],"genre_scores_gemma":[0.9969534,0.00003399278,0.0002595241,0.0001053411,0.00001242843,0.00004540216,0.00218002,0.00000867951,0.000401238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505188,"threshold_uncertainty_score":0.008380651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03779555001429525,"score_gpt":0.2931092968052542,"score_spread":0.2553137467909589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}