{"id":"W4200565535","doi":"10.1038/s41467-021-27077-y","title":"Androgen receptor and MYC equilibration centralizes on developmental super-enhancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia","funders":"National Cancer Institute; Institutes of Biomedical Sciences, Fudan University; Terry Fox Research Institute; Canadian Institutes of Health Research; China Scholarship Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Ministry of Education of the People's Republic of China; Canadian Centre for Applied Research in Cancer Control; University of Pittsburgh; National Institutes of Health; U.S. Department of Health and Human Services; Fudan University; U.S. Department of Defense","keywords":"Androgen receptor; Enhancer; Biology; Computational biology; Cell biology; Genetics; Transcription factor; Gene; Cancer; Prostate cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009607978,0.0001923643,0.0001206561,0.0001671243,0.0001795634,0.000238803,0.0002285385,0.0001467711,0.003059442],"category_scores_gemma":[0.0001038926,0.0001827776,0.0002174548,0.00008947851,0.0002500508,0.0001618245,0.0003450643,0.0004184695,0.0007093732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573664,"about_ca_system_score_gemma":0.0002275383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004900495,"about_ca_topic_score_gemma":0.001506602,"domain_scores_codex":[0.9998492,0.00001748334,0.000006141528,0.00005319261,0.00004419995,0.00002963988],"domain_scores_gemma":[0.999885,0.00001589373,0.0000301423,0.0000194337,0.00001359992,0.00003598888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005070015,0.000006606838,0.0003194676,0.00001164258,0.000001974661,0.0000317694,0.000006923616,0.00003124782,0.9976882,0.0003850447,0.00002119809,0.001445188],"study_design_scores_gemma":[0.000007627552,0.0001642325,0.0288296,0.000006641358,0.000009830035,0.000778834,0.00002708941,0.0009086148,0.9631715,0.0002097179,0.005881477,0.000004940453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779678,0.00310113,0.0110819,0.0001963058,0.00004721013,0.00002282203,0.0004476478,0.0001600115,0.00697518],"genre_scores_gemma":[0.9937974,0.0005243827,0.001511675,0.00005344446,0.00001007189,0.00001147983,0.0003617819,0.0000228418,0.003706898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059442,"threshold_uncertainty_score":0.01023489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791685743213348,"score_gpt":0.292909593394122,"score_spread":0.2749927359619885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}