{"id":"W4200568963","doi":"10.1093/brain/awab460","title":"Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"FDC Foundation; Sunnybrook Research Institute; Canadian Institutes of Health Research; Alzheimer Society; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute","keywords":"Nerve growth factor; Low-affinity nerve growth factor receptor; Neuroscience; Neuroprotection; Tropomyosin receptor kinase A; Cholinergic neuron; Basal forebrain; Medicine; Alzheimer's disease; Neurite; Cognitive decline; Cholinergic; Biology; Disease; Receptor; Internal medicine; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006271865,0.00008690473,0.0001240973,0.00003804305,0.00005587087,0.00002661286,0.00007380827,0.00006046976,0.00005187803],"category_scores_gemma":[0.0001614982,0.0000948733,0.00005210633,0.0002455849,0.00002732606,0.00003713023,0.00001232616,0.00008632671,0.0000362523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000020609,"about_ca_system_score_gemma":0.00002362247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003450434,"about_ca_topic_score_gemma":0.00007376412,"domain_scores_codex":[0.9994853,0.00003152353,0.000140133,0.0001300232,0.00007605025,0.0001369699],"domain_scores_gemma":[0.9995449,0.00016214,0.00002087554,0.0001676396,0.00006315295,0.00004133796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003245003,0.00004114601,0.000201915,0.00001007104,0.00006743922,0.000006701701,0.000367716,0.001731615,0.9908589,0.0003114955,0.002580286,0.00381944],"study_design_scores_gemma":[0.001311341,0.0002233189,0.1687513,0.0001002825,0.0002338607,0.0002123547,0.002237089,0.002000474,0.7112702,0.001486006,0.1111247,0.001049085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939675,0.0002548217,0.0018279,0.0004177344,0.0001147544,0.0001501826,0.00005594473,0.0002694604,0.002941682],"genre_scores_gemma":[0.9989011,0.0000422428,0.000561576,0.0002324065,0.0000288115,0.00003878168,0.00003712927,0.00002134064,0.0001365797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2795888,"threshold_uncertainty_score":0.3868821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828887663947864,"score_gpt":0.2235901392321188,"score_spread":0.2053012625926402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}