{"id":"W4200568963","doi":"10.1093/brain/awab460","title":"Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"FDC Foundation; Sunnybrook Research Institute; Canadian Institutes of Health Research; Alzheimer Society; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute","keywords":"Nerve growth factor; Low-affinity nerve growth factor receptor; Neuroscience; Neuroprotection; Tropomyosin receptor kinase A; Cholinergic neuron; Basal forebrain; Medicine; Alzheimer's disease; Neurite; Cognitive decline; Cholinergic; Biology; Disease; Receptor; Internal medicine; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149842,0.0004872792,0.0003091051,0.0002606587,0.0001363088,0.000181923,0.0001999174,0.0003536723,0.0007590844],"category_scores_gemma":[0.00009849618,0.0001411371,0.0002648139,0.000128858,0.0002633653,0.0002056465,0.0002225568,0.0004375187,0.0001624665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034076,"about_ca_system_score_gemma":0.0002664144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172727,"about_ca_topic_score_gemma":0.001620582,"domain_scores_codex":[0.9998872,0.00001281299,0.00001304852,0.00003062335,0.00002970765,0.00002659748],"domain_scores_gemma":[0.9999301,0.00001185368,0.00002238425,0.000006542923,0.00001258527,0.00001644149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006243765,0.00001472307,0.0000231757,0.00002950187,0.000002324887,0.00001319013,0.000009226212,0.00001907849,0.9987687,0.00001998579,0.00001593674,0.001021632],"study_design_scores_gemma":[0.0000157702,0.0008098242,0.001012385,0.000006263413,0.00002720671,0.0001254338,0.00001649897,0.0003301477,0.9967818,0.00002560372,0.0008445284,0.000004521161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898887,0.003296026,0.005057766,0.0001099052,0.00003934434,0.00004565782,0.0001487031,0.0001942725,0.0012197],"genre_scores_gemma":[0.9908575,0.002780108,0.004137585,0.00007308145,0.00001790484,0.00004986403,0.0001915679,0.00001922305,0.001873072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172727,"threshold_uncertainty_score":0.002539396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828887663947864,"score_gpt":0.2235901392321188,"score_spread":0.2053012625926402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}