{"id":"W4200569304","doi":"10.1099/acmi.cc2021.po0031","title":"Drug tolerance facilitates the evolution of drug resistance in Candida albicans","year":2021,"lang":"en","type":"article","venue":"Access Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Candida albicans; Biology; Epigenetics; Drug resistance; Fluconazole; Drug; Drug tolerance; Antifungal drug; Corpus albicans; Efflux; Genetic screen; Genetics; Phenotype; Computational biology; Pharmacology; Gene; Microbiology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008971662,0.0001459196,0.0002037951,0.0001946609,0.0001937932,0.0004813374,0.0001733237,0.0002934235,0.0009859444],"category_scores_gemma":[0.0001493276,0.0001185261,0.0001766511,0.0001893513,0.0001788321,0.0001858079,0.0002765302,0.0004574439,0.0002063388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215948,"about_ca_system_score_gemma":0.0001689235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000642346,"about_ca_topic_score_gemma":0.0008911921,"domain_scores_codex":[0.999871,0.000008423752,0.000007817654,0.000039416,0.00005490347,0.00001831618],"domain_scores_gemma":[0.9998645,0.00003082051,0.00003872388,0.00001674433,0.00002730465,0.00002198238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000252189,0.000009083739,0.0009195082,0.00002260161,0.000001995387,0.00002307241,0.00001519877,0.0001250383,0.99696,0.00007482382,0.00003326645,0.001790108],"study_design_scores_gemma":[0.000004578975,0.0002824742,0.03585887,0.00001125346,0.00001204302,0.0003112247,0.00007045624,0.004174444,0.9559296,0.000229577,0.003099918,0.0000155597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883552,0.0009247122,0.008373198,0.0001119462,0.00001876813,0.00003301154,0.0007330433,0.0001512289,0.001298974],"genre_scores_gemma":[0.98957,0.000636232,0.007769245,0.00009971466,0.000007829063,0.00004323506,0.0004396782,0.0000330123,0.001401047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009859444,"threshold_uncertainty_score":0.003298342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198933190264838,"score_gpt":0.2806327922535042,"score_spread":0.2686434603508558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}