{"id":"W4200569304","doi":"10.1099/acmi.cc2021.po0031","title":"Drug tolerance facilitates the evolution of drug resistance in Candida albicans","year":2021,"lang":"en","type":"article","venue":"Access Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Candida albicans; Biology; Epigenetics; Drug resistance; Fluconazole; Drug; Drug tolerance; Antifungal drug; Corpus albicans; Efflux; Genetic screen; Genetics; Phenotype; Computational biology; Pharmacology; Gene; Microbiology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000312408,0.0001181503,0.0003617368,0.00004762325,0.00006071339,0.000008802922,0.000225085,0.00006952237,0.0002069503],"category_scores_gemma":[0.0002405659,0.00008367174,0.00008748891,0.0003768586,0.0003441969,0.00008208686,0.00008446127,0.0002160939,0.00001099093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739998,"about_ca_system_score_gemma":0.0003453253,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404252,"about_ca_topic_score_gemma":0.05411563,"domain_scores_codex":[0.998776,0.0001883644,0.0003693223,0.0003425583,0.00005912354,0.0002646276],"domain_scores_gemma":[0.9989896,0.000239599,0.00009595041,0.0004520064,0.0001887289,0.00003407207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004473834,0.0001391082,0.6649694,0.0002350736,0.00003502029,0.00003923375,0.001399952,0.000008958791,0.3249339,0.0009805614,0.006587028,0.0002244375],"study_design_scores_gemma":[0.001436744,0.00002678852,0.899269,0.0003067343,0.00004586042,0.00002590632,0.00255265,0.00001135378,0.06887446,0.001770936,0.02547326,0.0002062809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838916,0.009705081,0.00008873666,0.003780901,0.0001387049,0.0002104076,0.00006034663,0.00001383604,0.002110358],"genre_scores_gemma":[0.9917203,0.0002063178,0.0001359803,0.0003814047,0.00002878655,0.00001379398,0.00004533689,0.000006984792,0.007461156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2560594,"threshold_uncertainty_score":0.9631443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198933190264838,"score_gpt":0.2806327922535042,"score_spread":0.2686434603508558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}