{"id":"W4200580191","doi":"10.1016/j.toxlet.2021.12.010","title":"Sex- and OGG1-dependent reversal of in utero ethanol-initiated changes in postnatal behaviour by neonatal treatment with the histone deacetylase inhibitor trichostatin A (TSA) in oxoguanine glycosylase 1 (Ogg1) knockout mice","year":2021,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; University of Toronto","keywords":"Trichostatin A; In utero; Histone deacetylase; Epigenetics; Offspring; Histone deacetylase inhibitor; Chemistry; DNA glycosylase; Endocrinology; Internal medicine; DNA repair; Biochemistry; Pharmacology; Fetus; Biology; Histone; Genetics; Medicine; Pregnancy; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002339666,0.0002104148,0.0002820891,0.0001316519,0.00002949296,0.00001037045,0.00009641676,0.0001976976,0.00001570559],"category_scores_gemma":[0.0000446361,0.0001791964,0.0000323122,0.0001810889,0.0001485057,0.000007099528,0.00008514245,0.0001799034,7.177345e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150607,"about_ca_system_score_gemma":0.00009069812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187537,"about_ca_topic_score_gemma":0.01291678,"domain_scores_codex":[0.9985512,0.0003089323,0.0002853249,0.0004355792,0.0001212479,0.0002977276],"domain_scores_gemma":[0.9994838,0.00008302632,0.0001294105,0.0002101284,0.00003429485,0.00005935952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004340553,0.0002775235,0.01016713,0.00001457838,0.00003055399,0.0007792561,0.0009322906,0.00005205283,0.985551,0.000001638826,0.0001199065,0.001640002],"study_design_scores_gemma":[0.00452877,0.001206201,0.01108212,0.00002329552,0.00002774096,0.00006739074,0.0004521371,0.00004117596,0.9819384,0.000001670041,0.0004321663,0.0001989421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917303,0.002744494,0.00007839969,0.004862437,0.00006226044,0.0003456875,0.0001603369,0.000004560904,0.00001148083],"genre_scores_gemma":[0.9977139,0.0004282111,0.000250344,0.0009396134,0.00003390788,0.00007431812,0.0004006454,0.00002252069,0.000136565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01239803,"threshold_uncertainty_score":0.7307417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047814397846921,"score_gpt":0.2573338728365896,"score_spread":0.2468557288581204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}