{"id":"W4200580191","doi":"10.1016/j.toxlet.2021.12.010","title":"Sex- and OGG1-dependent reversal of in utero ethanol-initiated changes in postnatal behaviour by neonatal treatment with the histone deacetylase inhibitor trichostatin A (TSA) in oxoguanine glycosylase 1 (Ogg1) knockout mice","year":2021,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; University of Toronto","keywords":"Trichostatin A; In utero; Histone deacetylase; Epigenetics; Offspring; Histone deacetylase inhibitor; Chemistry; DNA glycosylase; Endocrinology; Internal medicine; DNA repair; Biochemistry; Pharmacology; Fetus; Biology; Histone; Genetics; Medicine; Pregnancy; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509424,0.0007476674,0.0005404166,0.0007472101,0.0002503261,0.0003388691,0.0005686916,0.0005364658,0.003337047],"category_scores_gemma":[0.0001958539,0.0004213863,0.0005588759,0.0002128074,0.0007717395,0.0004204015,0.0003775841,0.001763384,0.0006214615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625542,"about_ca_system_score_gemma":0.0004854521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708442,"about_ca_topic_score_gemma":0.004361724,"domain_scores_codex":[0.999747,0.00002558918,0.00002498616,0.00007858605,0.00004952628,0.00007426278],"domain_scores_gemma":[0.9994935,0.0000379871,0.0001793185,0.00006073981,0.00003255741,0.0001958986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005678431,0.00005253368,0.0003315286,0.00001592137,0.000009378507,0.0001063169,0.00003293357,0.00002990083,0.9976857,0.00007117743,0.00004918577,0.001047684],"study_design_scores_gemma":[0.0000555874,0.0005883342,0.01164535,0.00001004214,0.00003697453,0.0002687404,0.00009500948,0.0003260348,0.9856764,0.00007783915,0.001206341,0.00001324953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949979,0.0008958896,0.001491443,0.0002620243,0.00009719894,0.00001994369,0.0009754745,0.0002031236,0.001057046],"genre_scores_gemma":[0.9818429,0.001289183,0.001737388,0.0001786203,0.00003390052,0.00007953025,0.0009774895,0.0002306991,0.01363024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003337047,"threshold_uncertainty_score":0.01116359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047814397846921,"score_gpt":0.2573338728365896,"score_spread":0.2468557288581204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}