{"id":"W4200592086","doi":"10.3389/fcell.2021.789959","title":"Mitochondria Endoplasmic Reticulum Contact Sites (MERCs): Proximity Ligation Assay as a Tool to Study Organelle Interaction","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Endoplasmic reticulum; Organelle; Proximity ligation assay; Mitochondrion; Cell biology; Membrane contact site; Biology; Endogeny; Calcium signaling; Förster resonance energy transfer; STIM1; Computational biology; Biophysics; Fluorescence; Biochemistry; Signal transduction; Membrane protein; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007442342,0.001008314,0.001545443,0.003196783,0.0002712267,0.001115392,0.0009962929,0.001157908,0.001768348],"category_scores_gemma":[0.0005978149,0.000418659,0.0005862,0.002743013,0.0006011093,0.001639506,0.0007006958,0.001965142,0.002466636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000844037,"about_ca_system_score_gemma":0.0007480287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007615376,"about_ca_topic_score_gemma":0.00110702,"domain_scores_codex":[0.9996569,0.00005438575,0.00003654478,0.00007540121,0.0001478465,0.00002887326],"domain_scores_gemma":[0.9996688,0.0001527701,0.00005137977,0.00001435311,0.00008702916,0.00002570919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009570671,0.000111821,0.0003247234,0.02452647,0.0001176241,0.0003716819,0.00009498348,0.0005683838,0.03516793,0.007934782,0.02077559,0.9099104],"study_design_scores_gemma":[0.00001152112,0.0001350638,0.0009758014,0.00167648,0.0001415625,0.001753791,0.00005974086,0.0001787229,0.01276834,0.001837803,0.9804152,0.00004599102],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003253383,0.9959841,0.001217754,0.0002059647,0.0001854749,0.00001325947,0.00005558493,0.00002961289,0.001982988],"genre_scores_gemma":[0.001601543,0.9953001,0.001323513,0.0001706443,0.0000762391,0.0000248782,0.0001289348,0.000006872692,0.001367338],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003196783,"threshold_uncertainty_score":0.0061239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751777001510498,"score_gpt":0.2806612193479994,"score_spread":0.2631434493328944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}