{"id":"W4200592628","doi":"10.1158/1535-7163.targ-21-p062","title":"Abstract P062: The CL2A-SN38 linker-payload system conjugated to trastuzumab results in improved cellular cytotoxicity over time relative to T-DM1","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Linker; Cytotoxicity; Chemistry; Conjugate; Trastuzumab; Conjugated system; Antibody-drug conjugate; Internalization; Prodrug; Endosome; Cancer cell; Biophysics; Combinatorial chemistry; Biochemistry; Monoclonal antibody; Cancer; In vitro; Antibody; Biology; Intracellular; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000834065,0.0004606067,0.0007201888,0.0002089488,0.0001445618,0.0001147359,0.0004690175,0.000345786,0.0002384466],"category_scores_gemma":[0.0001872536,0.0003751642,0.0002362362,0.001462406,0.0001204655,0.00007480767,0.0002094376,0.001162804,0.0002742344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002084816,"about_ca_system_score_gemma":0.001313683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092164,"about_ca_topic_score_gemma":0.0004136699,"domain_scores_codex":[0.9957529,0.0003988612,0.0008671614,0.000967906,0.001062938,0.000950192],"domain_scores_gemma":[0.9972752,0.0002225369,0.000158831,0.001337427,0.000558812,0.0004472208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001614352,0.0002024476,0.0003616988,0.000188208,0.0004736193,0.001076168,0.002460019,0.0006396246,0.9871453,0.0001046934,0.0005199067,0.005213941],"study_design_scores_gemma":[0.005600098,0.0007933468,0.01658799,0.001328245,0.0002719427,0.00004300064,0.0006381173,0.005520478,0.9278391,0.00005939206,0.04058746,0.0007308481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970858,0.003392355,0.001909143,0.01500141,0.0004329968,0.00338002,0.0003817494,0.0001761966,0.004468105],"genre_scores_gemma":[0.9897645,0.0001309982,0.0004987285,0.00738805,0.0002210085,0.000361079,0.00006060584,0.0001382696,0.001436838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05930624,"threshold_uncertainty_score":0.99987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03613944612334209,"score_gpt":0.3372637995773403,"score_spread":0.3011243534539982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}