{"id":"W4200592628","doi":"10.1158/1535-7163.targ-21-p062","title":"Abstract P062: The CL2A-SN38 linker-payload system conjugated to trastuzumab results in improved cellular cytotoxicity over time relative to T-DM1","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Linker; Cytotoxicity; Chemistry; Conjugate; Trastuzumab; Conjugated system; Antibody-drug conjugate; Internalization; Prodrug; Endosome; Cancer cell; Biophysics; Combinatorial chemistry; Biochemistry; Monoclonal antibody; Cancer; In vitro; Antibody; Biology; Intracellular; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079034,0.0002782558,0.0001462421,0.0001206995,0.00008514312,0.0001941126,0.0001898611,0.0002604098,0.00293607],"category_scores_gemma":[0.0001084022,0.00007338677,0.0001208322,0.0001308464,0.000117,0.00019866,0.00009651394,0.0002923127,0.0005259191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003289996,"about_ca_system_score_gemma":0.000173713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000908778,"about_ca_topic_score_gemma":0.0006369317,"domain_scores_codex":[0.9998757,0.00001421323,0.000008763283,0.00003272329,0.00003731277,0.00003129179],"domain_scores_gemma":[0.9999322,0.00000898038,0.00001857206,0.000006047875,0.00001657702,0.00001764796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002627816,0.00003614692,0.00006100145,0.00001767597,0.000002812215,0.00002956563,0.000007878633,0.00006863526,0.9984106,0.00003121309,0.00009152653,0.0009800484],"study_design_scores_gemma":[0.00001100261,0.0003155257,0.000433773,0.00000128109,0.000002216381,0.00003906929,0.000003706855,0.0004598876,0.9981816,0.000005367595,0.0005450618,0.000001562521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961689,0.000397431,0.001328598,0.00005280289,0.00002037446,0.00001721806,0.0002621703,0.00009427813,0.001658177],"genre_scores_gemma":[0.9936236,0.0001721825,0.001265411,0.00002662128,0.000004944196,0.00001504774,0.0004976754,0.00002746989,0.004367107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00293607,"threshold_uncertainty_score":0.00982213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03613944612334209,"score_gpt":0.3372637995773403,"score_spread":0.3011243534539982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}